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The Relationship Between Intestinal Hypoperfusion and Serum D-Lactate Levels During Experimental Intra-Abdominal Hypertension

Digestive Diseases and Sciences volume 51, pages 2400–2403 (2006)Cite this article

Abstract

Intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) may result from several clinic situations and carries high morbidity and mortality risk, particularly in intensive care unit patients. The clinical spectrum changes from splanchnic hypoperfusion and intestinal ischemia to multiple organ failure. Previous studies demonstrated that serum D-lactate levels may be an early indicator in intestinal ischemia. This study aimed to investigate the relationship between intestinal ischemia and serum D-lactate levels during experimental IAH. Thirty-two male Wistar Albino rats weighing 250±50 g were divided into four groups. Three different intra-abdominal pressure (IAP) levels supplied by placement of an intraperitoneal Peritofix catheter and iso-osmotic polyethylene glycol infusion. Each of the IAP levels (15, 20, and 25 mm Hg groups) was checked with the monitor system and fixed for an hour. Control-group animals were not subjected to increased IAP. One hour later, 5-ml blood samples were taken for measurement of serum D-lactate levels and 2-cm intestinal tissue samples were taken 5 cm proximal to the ileocecal valve for histopathologic examination. Elevated serum D-lactate levels were recorded in animals with higher IAP levels.There was a positive correlation between serum D-lactate levels and IAP levels. Histological examinations of the intestinal tissue samples showed no significant pathologic changes in concordance with intestinal ischemia. Serum D-lactate levels may be an early indicator for increased IAP pressure before intestinal ischemic changes occur.

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Affiliations

  1. Third Department of Surgery, Ankara Numune Teaching and Research Hospital, Şehit Adem Yavuz Sokak, No. 7/11 Kizilay, Ankara 06100, Turkey

    Arife Polat Duzgun, Baris Gulgez, Anil Özmutlu, Didem Ertorul, Güler Bugdayci, Nurten Akyurek & Faruk Coskun

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  1. Arife Polat Duzgun
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  2. Baris Gulgez
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Correspondence to Faruk Coskun.

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Duzgun, A.P., Gulgez, B., Özmutlu, A. et al. The Relationship Between Intestinal Hypoperfusion and Serum D-Lactate Levels During Experimental Intra-Abdominal Hypertension. Dig Dis Sci 51, 2400–2403 (2006). https://doi.org/10.1007/s10620-006-9334-7

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  • DOI: https://doi.org/10.1007/s10620-006-9334-7

Keywords

  • D-Lactate
  • Intestinal hypoperfusion
  • Intra-abdominal pressure
  • Abdominal compartment syndrome