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Large Cell Lymphoma Presenting as a Flare of Colitis in a Patient with Common Variable Immune Deficiency

Digestive Diseases and Sciences volume 52, pages 830–834 (2007)Cite this article

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References

  1. Hammarstrom L, Vorechovsky I, Webster D (2000) Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin Exp Immunol 120:225–231

    PubMed  Article  CAS  Google Scholar 

  2. Hermaszewski RA, Webster AD (1993) Primary hypogammaglobulinaemia: a survey of clinical manifestations and complications. Q J Med 86:31–42

    PubMed  CAS  Google Scholar 

  3. Saiki O, Ralph P, Cunningham-Rundles C, et al. (1982) Three distinct stages of B-cell defects in common varied immunodeficiency. Proc Natl Acad Sci USA 79:6008–6012

    PubMed  Article  CAS  Google Scholar 

  4. Cunningham-Rundles C, Bodian C (1999) Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol 92:34–48

    PubMed  Article  CAS  Google Scholar 

  5. Cunningham-Rundles S, Cunningham-Rundles C, Siegal FP, et al. (1981) Defective cellular immune response in vitro in common variable immunodeficiency. J Clin Immunol 65–72

  6. Stagg AJ, Funauchi M, Knight SC, et al. (1994) Failure in antigen responses by T cells from patients with common variable immunodeficiency (CVID). Clin Exp Immunol 96:48–53

    PubMed  CAS  Article  Google Scholar 

  7. Kondratenko I, Amlot PL, Webster AD, et al. (1997) Lack of specific antibody response in common variable immunodeficiency (CVID) associated with failure in production of antigen-specific memory T cells. MRC Immunodeficiency Group. Clin Exp Immunol 108:9–13

    PubMed  Article  CAS  Google Scholar 

  8. Bryant A, Calver NC, Toubi E, et al. (1990) Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2. Clin Immunol Immunopathol 56:239–248

    PubMed  Article  CAS  Google Scholar 

  9. Cunningham-Rundles C (1989) Clinical and immunologic analyses of 103 patients with common variable immunodeficiency. J Clin Immunol 9:22–33

    PubMed  Article  CAS  Google Scholar 

  10. Sneller MC, Strober W, Eisenstein E, et al. (1993) NIH conference. New insights into common variable immunodeficiency. Ann Intern Med 118:720–730

    PubMed  CAS  Google Scholar 

  11. Washington K, Stenzel TT, Buckley RH, et al. (1996) Gastrointestinal pathology in patients with common variable immunodeficiency and X-linked agammaglobulinemia. Am J Surg Pathol 20:1240–1252

    PubMed  Article  CAS  Google Scholar 

  12. Lai Ping So A, Mayer L (1997) Gastrointestinal manifestations of primary immunodeficiency disorders. Semin Gastrointest Dis 8:22–32

    PubMed  CAS  Google Scholar 

  13. Kutukculer N, Yagci RV, Aydogdu S, et al. (2001) Chronic inflammatory bowel disease in a patient with common variable immunodeficiency. Turk J Pediatr 43:88–90

    PubMed  CAS  Google Scholar 

  14. Feugier P, Van Hoof A, Sebban C, et al. (2005) Long-term results of the R-CHOP Study in the treatment of elderly patients with diffuse large B-cell lymphoma: a study by the Groupe d’Etude des Lymphomes de l’Adulte. J Clin Oncol 23:4117–4126

    PubMed  Article  CAS  Google Scholar 

  15. Cunningham-Rundles C, Siegal FP, Cunningham-Rundles S, et al. (1987) Incidence of cancer in 98 patients with common varied immunodeficiency. J Clin Immunol 7:294–299

    PubMed  Article  CAS  Google Scholar 

  16. Bernstein CN, Blanchard JF, Kliewer E, et al. (2001) Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer 91:854–862

    PubMed  Article  CAS  Google Scholar 

  17. Palli D, Trallori G, Bagnoli S, et al. (2000) Hodgkin's disease risk is increased in patients with ulcerative colitis. Gastroenterology 119:647–653

    PubMed  Article  CAS  Google Scholar 

  18. Farrell RJ, Ang Y, Kileen P, et al. (2000) Increased incidence of non–Hodgkin's lymphoma in inflammatory bowel disease patients on immunosuppressive therapy but overall risk is low. Gut 47:514–519

    PubMed  Article  CAS  Google Scholar 

  19. Arseneau KO, Stukenborg GJ, Connors AF Jr, et al. (2001) The incidence of lymphoid and myeloid malignancies among hospitalized Crohn's disease patients. Inflamm Bowel Dis 7:106–112

    PubMed  Article  CAS  Google Scholar 

  20. Loftus EV Jr, Tremaine WJ, Habermann TM, et al. (2000) Risk of lymphoma in inflammatory bowel disease. Am J Gastroenterol 95:2308–2312

    PubMed  Article  Google Scholar 

  21. Lewis JD, Bilker WB, Brensinger C, et al. (2001) Inflammatory bowel disease is not associated with an increased risk of lymphoma. Gastroenterology 121:1080–1087

    PubMed  Article  CAS  Google Scholar 

  22. Askling J, Brandt L, Lapidus A, et al. (2005) Risk of haematopoietic cancer in patients with inflammatory bowel disease. Gut 54:617–622

    PubMed  Article  CAS  Google Scholar 

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Acknowledgement

Aaron P. Rapoport is a Clinical Scholar of the Leukemia and Lymphoma Society.

Author information

Affiliations

  1. Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Veterans Affairs, Maryland Health Care System, Baltimore, Maryland, USA

    Megan Dunnigan

  2. Department of Medicine, Division of Hematology and Oncology and Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland, USA

    Aaron P. Rapoport

  3. Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

    Keya Hosseinzadeh

  4. Department of Pathology, Johns Hopkins Medical Institution, Baltimore, Maryland, USA

    Christopher D. Gocke & Raymond K. Cross

  5. Veterans Affairs, Maryland Heath Care System, Baltimore, Maryland, USA

    Harris Yfantis & Raymond K. Cross

  6. 22 South Greene Street, N3W62, Baltimore, Maryland, 21201, USA

    Raymond K. Cross

Authors
  1. Megan Dunnigan
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  2. Harris Yfantis
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  3. Aaron P. Rapoport
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  4. Keya Hosseinzadeh
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  5. Christopher D. Gocke
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  6. Raymond K. Cross
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Corresponding author

Correspondence to Raymond K. Cross.

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Dunnigan, M., Yfantis, H., Rapoport, A.P. et al. Large Cell Lymphoma Presenting as a Flare of Colitis in a Patient with Common Variable Immune Deficiency. Dig Dis Sci 52, 830–834 (2007). https://doi.org/10.1007/s10620-006-9299-6

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  • DOI: https://doi.org/10.1007/s10620-006-9299-6

Keywords

  • Common variable immunodeficiency
  • Colitis
  • Inflammatory bowel disease
  • Lymphoma