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Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection

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Abstract

We investigated the biochemical markers of bone metabolism in children with Helicobacter pylori infection. Biochemical markers of bone metabolism and serum levels of vitamin B12, ferritin and estradiol were measured in 41 H. pylori-positive (+) children (23 girls, 18 boys; aged 11.8±3 years). Serum levels of intact parathyroid hormone, ß-collagen I carboxy terminal telopeptide, total alkaline phosphatase (ALP), bone-specific ALP, N-terminal cross-links of human procollagen type I, N-mid-osteocalcin, calcium, phosphate, ferritin, and estradiol did not differ significantly between H. pylori(+) and H. pylori negative (−) children. Vitamin B12 levels were significantly decreased in H. pylori(+) compared to H. pylori(−) children. H. pylori infection was not accompanied by significant changes in markers of bone metabolism in children, although vitamin B12 levels were decreased. Further studies are required to clarify whether H. pylori infection causes time-dependent changes in bone turnover markers during the long course of this inflammatory disease.

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Acknowledgments

This study was supported by the Akdeniz University Research Projects Unit. The authors thank Dr. Levent Donmez for his contribution in data analysis.

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Authors and Affiliations

  1. Central Laboratory, Clinical Biochemistry Unit, Akdeniz University, Medical Faculty, 07070, Antalya, Turkey

    Sebahat Ozdem

  2. Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Akdeniz University, Medical Faculty, Antalya, Turkey

    Mustafa Akcam, Aygen Yilmaz & Reha Artan

  3. Department of Microbiology, Akdeniz University, Medical Faculty, Antalya, Turkey

    Meral Gultekin

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  1. Sebahat Ozdem
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  2. Mustafa Akcam
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Correspondence to Sebahat Ozdem.

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Ozdem, S., Akcam, M., Yilmaz, A. et al. Biochemical Markers of Bone Metabolism in Children with Helicobacter pylori Infection. Dig Dis Sci 52, 967–972 (2007). https://doi.org/10.1007/s10620-006-9292-0

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  • DOI: https://doi.org/10.1007/s10620-006-9292-0

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