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Increased Risk of Papillary Thyroid Cancer in Celiac Disease

Digestive Diseases and Sciences volume 51, pages 1875–1877 (2006)Cite this article

Abstract

Patients with celiac disease have an increased rate of malignancies that are not limited to lymphomas. Thyroid carcinoma has not previously been associated with celiac disease. However, among a cohort of patients with celiac disease, we identified an increased risk of papillary carcinoma of the thyroid, standard morbidity ratio of 22.52 (95% confidence interval 14.90–34.04; P < .001), compared to United States national surveillance data. These patients were on a gluten-free diet. Only 1 had Hashimoto's thyroiditis, suggesting that mechanisms apart from autoimmune thyroiditis contribute to the increased risk of carcinoma of the thyroid in celiac disease.

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Affiliations

  1. Department of Medicine, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, Room 645, New York, 10032, New York, USA

    Laura Kent, Russell McBride, Robert McConnell, Alfred I. Neugut & Peter H. R. Green

  2. Department of Pathology Columbia University College of Physicians and Surgeons, New York, New York, USA

    Govind Bhagat

  3. Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, USA

    Russell McBride & Alfred I. Neugut

  4. Department of Epidemiology, Mailman School of Public Health at Columbia University, New York, New York, USA

    Russell McBride & Alfred I. Neugut

Authors
  1. Laura Kent
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  2. Russell McBride
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  3. Robert McConnell
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  4. Alfred I. Neugut
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  5. Govind Bhagat
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  6. Peter H. R. Green
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Correspondence to Peter H. R. Green.

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Kent, L., McBride, R., McConnell, R. et al. Increased Risk of Papillary Thyroid Cancer in Celiac Disease. Dig Dis Sci 51, 1875–1877 (2006). https://doi.org/10.1007/s10620-006-9240-z

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  • DOI: https://doi.org/10.1007/s10620-006-9240-z

Keywords

  • Celiac disease
  • Papillary carcinoma
  • Thyroiditis
  • Hashimoto's thyroiditis