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Curcumin Prevents the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis

Digestive Diseases and Sciences volume 52, pages 2993–2998 (2007)Cite this article

Abstract

Curcumin is a phenolic natural product isolated from the rhizome of Curcuma longa (turmeric). We evaluated the effects of curcumin on the development of dextran sulfate sodium (DSS)-induced experimental colitis. BALB/c mice were fed a chow containing either 3.5% (wt/wt) DSS or 3.5% DSS + 2.0% (wt/wt) curcumin. The body weight loss was more apparent in DSS-treated mice than in DSS + curcumin-treated mice. The disease activity index, histological colitis score, and MPO activity were all significantly higher in DSS-treated mice than in DSS plus curcumin-treated mice. Microscopically, mucosal edema, cellular infiltration, and epithelial disruption were much more severe in DSS-treated mice than in DSS + curcumin-treated mice. In DSS + curcumin-treated mice, NF-κB activation was blocked in the mucosa. In conclusion, the development of DSS-induced colitis was significantly attenuated by curcumin. Being a nontoxic natural dietary product, curcumin could be useful in treatment of IBD patients.

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Affiliations

  1. Department of Internal Medicine, Shiga University of Medical Science, Seta Tukinowa, Otsu, 520-2192, Japan

    Yasuyuki Deguchi, Akira Andoh, Osamu Inatomi, Yuhki Yagi, Shigeki Bamba, Yoshio Araki, Kazunori Hata, Tomoyuki Tsujikawa & Yoshihide Fujiyama

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  1. Yasuyuki Deguchi
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  2. Akira Andoh
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  3. Osamu Inatomi
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  4. Yuhki Yagi
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  7. Kazunori Hata
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  9. Yoshihide Fujiyama
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Correspondence to Akira Andoh.

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Deguchi, Y., Andoh, A., Inatomi, O. et al. Curcumin Prevents the Development of Dextran Sulfate Sodium (DSS)-Induced Experimental Colitis. Dig Dis Sci 52, 2993–2998 (2007). https://doi.org/10.1007/s10620-006-9138-9

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  • DOI: https://doi.org/10.1007/s10620-006-9138-9

Key Words

  • Inflammatory bowel disease
  • NF-κB
  • Antioxidant
  • T cells