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Aspects of Digestive Tract Tumors in Down Syndrome: A Literature Review

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Abstract

The purpose of this study was to describe the digestive neoplasms found in persons with Down syndrome. Due to intellectual disability, persons with Down syndrome do not convey their symptoms and pain, leading to delayed diagnosis and potentially worse outcome. It is thus important to know which organs are at risk for tumors and possible tumor risk factors. In a review of the literature, we found 13 benign tumors and 127 cancers in 1 fetus, 8 children, and 131 adults with Down syndrome. The review suggests a decreased incidence of digestive cancer, however, with a possible increased incidence of neoplasms of the pancreas and gallbladder. The distribution of cancers is distinct from that in the general population and that in persons with other intellectual disabilities who share the same life conditions, suggesting that constitutional protective factors exist. This review may allow a more specific, adapted medical follow-up for persons with Down syndrome and could help to elucidate the oncogenesis of digestive neoplasms.

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Acknowledgments

A grant from the Fondation Jérôme Lejeune supported this study. We thank Drs. C. M. J. Böhmer, F. Gonzales-Crussi, G. Gridley, and S. Sullivan for complementary information concerning their publications. We acknowledge Drs. Jacques Roger and Bernard Lemmet, who provided complementary information on their patients, and Mrs. Marie-Sylvie Richard, who translated an article in Dutch. We thank Christiane Satgé and Mary Renaud for preparation of the manuscript.

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  1. Laboratoire d’Anatomie Pathologique, Centre Hospitalier, 19 000, Tulle, France

    Daniel Satgé & Marie-Laure Portal

  2. Epidemiology, International Agency for Research on Cancer, and Institut National de la Santé et de la Recherche Médicale, 69 872, Lyon Cedex 8, France

    Annie J. Sasco

  3. Laboratoire de Cytogénétique Hôpital Necker, 75 743, Paris, France

    Michel J. J. Vekemans

  4. Laboratoire d’Anatomie et Cytologie Pathologique, Hôpital-Saint Antoine, 75 000, Paris, France

    Jean-François Fléjou

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  1. Daniel Satgé
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Satgé, D., Sasco, A.J., Vekemans, M.J.J. et al. Aspects of Digestive Tract Tumors in Down Syndrome: A Literature Review. Dig Dis Sci 51, 2053–2061 (2006). https://doi.org/10.1007/s10620-006-9131-3

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