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Musculoskeletal Complaints and Serum Autoantibodies Associated with Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease

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Abstract

We sought to compare the musculoskeletal symptoms and immune markers found in chronic hepatitis C (HCV) and nonalcoholic fatty liver disease (NAFLD). Patients with HCV or NAFLD answered a questionnaire and donated serum for autoantibody testing. Univariate analysis between the HCV and NAFLD groups revealed joint pain in 67% of the HCV group and 65% of the NAFLD group. Those with joint pain reported inflammatory characteristics that were similar between the groups. The presence of a positive rheumatoid factor and cryoglobulins was higher in the HCV group, however both groups had a similar prevalence of a low positive antinuclear antibody (ANA). We conclude that the NAFLD group reported a higher amount of joint pain and inflammatory joint symptoms than anticipated. We were unable to determine a variable that predicted the presence of joint pain. Therefore, more investigation is needed to determine whether these findings are due to liver disease alone.

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Authors and Affiliations

  1. Division of Rheumatology, Penn State Milton S. Hershey Medical Center, 500 University Drive P. O. Box 850, H038, Hershey, PA, 17033, USA

    Sharon E. Banks (Assistant Professor of Medicine)

  2. Division of Gastroenterology and Hepatology, Penn State Milton S. Hershey Medical Center, 500 University Drive, P. O. Box 850, Hershey, PA, 17033, USA

    Thomas R. Riley III (Associate Professor of Medicine)

  3. Microbiology and Immunology and Pharmacology Chief,Division of Rheumatology, Penn State Milton S. Hershey Medical Center, 500 University Drive, P. O. Box 850, Hershey, PA, 17033, USA

    Stanley J Naides (Professor of Medicine)

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  1. Sharon E. Banks
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  2. Thomas R. Riley III
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  3. Stanley J Naides
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Correspondence to Sharon E. Banks.

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Banks, S.E., Riley III, T.R. & Naides, S.J. Musculoskeletal Complaints and Serum Autoantibodies Associated with Chronic Hepatitis C and Nonalcoholic Fatty Liver Disease. Dig Dis Sci 52, 1177–1182 (2007). https://doi.org/10.1007/s10620-006-9109-7

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  • DOI: https://doi.org/10.1007/s10620-006-9109-7

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