The Efficacy of an Herbal Medicine, Carmint, on the Relief of Abdominal Pain and Bloating in Patients with Irritable Bowel Syndrome: A Pilot Study

Abstract

Carmint contains total extracts of Melissa officinalis, Mentha spicata, and Coriandrum sativum, which have antispasmodic, carminative, and sedative effects. As abdominal pain/discomfort and bloating are commonly observed in patients with irritable bowel syndrome, we decided to evaluate the effectiveness of Carmint in relieving these symptoms in irritable bowel syndrome patients. We randomly assigned 32 irritable bowel syndrome patients to receive either Carmint or placebo, plus Loperamide or psyllium (based on their predominant bowel function), for 8 weeks. T-test analysis of the results showed that the severity and frequency of abdominal pain/discomfort were significantly lower in the Carmint group than the placebo group at the end of the treatment (P=0.016 and P=0.001, respectively), as were the severity and frequency of bloating (P=0.02 and P=0.002, respectively). This pilot study suggests that Carmint plus loperamide or Carmint plus psyllium (depending on the irritable bowel syndrome subtype) might be effective in these patients.

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References

  1. 1.

    Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Muller-Lissner SA (1999) Functional bowel disorders and functional abdominal pain. Gut 45:43–47

    Google Scholar 

  2. 2.

    Watson AR, Bowling TE (2005) Irritable bowel syndrome: diagnosis and symptom management. Br J Commun Nurs 10:118–122

    Google Scholar 

  3. 3.

    Whitehead WE (1999) Patient subgroups in irritable bowel syndrome that can be defined by symptom evaluation and physical examination. Am J Med 107:33–40

    Article  Google Scholar 

  4. 4.

    Talley NJ, Zinsmeister AR, Melton J (1995) Irritable bowel syndrome in a community: symptom subgroups, risk factors, and health care utilization. Am J Epidemiol 142:76–83

    PubMed  CAS  Google Scholar 

  5. 5.

    Drossman DA, Morris CB, Hu Y, Toner BB, Diamant N, Leserman J, Shetzline M, Dalton C, Bangdiwala SI (2005) A prospective assessment of bowel habit in irritable bowel syndrome in women: defining an alternator. Gastroenterology 128:580–589

    PubMed  Article  Google Scholar 

  6. 6.

    Creed F, Ratcliffe J, Fernandez L, Tomenson B, Palmer S, Rigby C, Guthrie E, Read N, Thompson D (2001) Health-related quality of life and health care costs in severe, refractory irritable bowel syndrome. Ann Intern Med 134:860–868

    PubMed  CAS  Google Scholar 

  7. 7.

    Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, Whitehead WE, Janssens J, Funch-Jensen P, Corazziari E, Richter JE, Koch GG (1993) US householder survey of functional gastrointestinal disorders: Prevalence, sociodemography and health impact. Dig Dis Sci 38:1569–1580

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Heaton KW, O’Donnell LJD, Braddon FEM, Moutford RA, Hughes AO, Cripps PJ (1992) Symptoms of irritable bowel syndrome in a British urban community: Consulters and nonconsulters. Gastroenterology 102:1962–1967

    PubMed  CAS  Google Scholar 

  9. 9.

    Zuckerman MJ, Guerra LG, Drossman DA, Foland JA, Gregory GG (1995) Comparison of bowel patterns in Hispanic and non-Hispanic whites. Dig Dis Sci 40:1761–1769

    Google Scholar 

  10. 10.

    Massarrat S, Saberi-Firoozi M, Soleimani A, Himmelmann GW, Hitzges M, Keshavarz H (1995) Peptic ulcer disease, irritable bowel syndrome and constipation in two populations in Iran. Eur J Gastroentroenterol Hepatol 7:427–433

    CAS  Google Scholar 

  11. 11.

    Thompson WG, Longstreth GF, Drossman DA, Heaton KW, Irvine EJ, Müller-Lissner SA (2000) (C) Functional bowel disorders and (D) functional abdominal pain. In: Drossman DA, Talley NJ, Thompson WG, Corazziari E, Whitehead WE (eds). Rome II: The functional gastrointestinal disorders: Diagnosis, pathophysiology and treatment. A multinational consensus, 2nd ed. Degnon Associates, McLean, VA, pp 351–432

  12. 12.

    Jarrett M, Heitkemper MM, Bond EF, Georges J (1994) Comparison of diet composition in women with and without functional bowel disorder. Gastroenterol Nurs 6:253

    Article  Google Scholar 

  13. 13.

    Distrutti E, Azpiroz F, Soldevilla A, Malagelada JR (1999) Gastric wall tension determines perception of gastric distention. Gastroenterology 116:1035–1042

    PubMed  Article  CAS  Google Scholar 

  14. 14.

    Thumshirn M, Camilleri M, Choi MG, Zinsmeister AR (1999) Modulation of gastric sensory and motor functions by nitrergic and alpha2-adrenergic agents in humans. Gastroenterology 116:573–585

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    Malcolm A, Phillips SF, Camilleri M, Hanson RB (1997) Pharmacological modulation of rectal tone alters perception of distention in humans. Am J Gastroenterol 92:2073–2079

    PubMed  CAS  Google Scholar 

  16. 16.

    Cann PA, Read NW, Holdsworth CD (1984) What is the benefit of coarse wheat bran in patients with irritable bowel syndrome? Gut 25:168–173

    PubMed  Article  CAS  Google Scholar 

  17. 17.

    Voderholzer WA, Schatke W, Muhldorfer BE, Klauser AG, Birkner B, Muller-Lissner SA (1997) Clinical response to dietary fiber treatment of chronic constipation. Am J Gastroenterol 92:95–98

    PubMed  CAS  Google Scholar 

  18. 18.

    Vassallo MJ, Camilleri M, Phillips SF, Steadman CJ, Talley NJ, Hanson RB, Haddad AC (1992) Colonic tone and motility in patients with irritable bowel syndrome. Mayo Clin Proc 67:725–731

    PubMed  CAS  Google Scholar 

  19. 19.

    Cann PA, Read NW, Holdsworth CD, Barends D (1984) Role of loperamide and placebo in management of irritable bowel syndrome. Dig Dis Sci 29:239–247

    PubMed  Article  CAS  Google Scholar 

  20. 20.

    Camilleri M (1999) Therapeutic approach to the patient with irritable bowel syndrome. Am J Med 107(5A):27S–32S

    PubMed  Article  CAS  Google Scholar 

  21. 21.

    Fleming T (2000) PDR for herbal medicines, 2nd ed. Medical Economics

  22. 22.

    Ballard C, O’Brien J, Reichelt K, Perry E (2002) Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa. J Clin Psychiatry 63:553–558

    PubMed  Google Scholar 

  23. 23.

    Sweetman SC (2005) Martindale, the complete drug reference, 34th ed. Pharmaceutical Press, p 1749

  24. 24.

    Drossman DA (2000) The functional gastrointestinal disorders, their diagnosis and the Rome II process. In: Drossman DA, Talley NJ, Thompson WG, Corazziari E, Whitehead WE (eds). Rome II: The functional gastrointestinal disorders: Diagnosis, pathophysiology and treatment. A multinational consensus, 2nd ed. Degnon Associates, McLean, VA, pp 1–29

  25. 25.

    Quartero A, Meineche-Schmidt V, Muris J, Rubin G, de Wit N (2005) Bulking agents, antispasmodic and antidepressant medication for the treatment of irritable bowel syndrome. Cochrane Database Syst Rev 18:CD003460

    Google Scholar 

  26. 26.

    De Ponti R, Malagelada JR (1998) Functional gut disorders: from motility to sensitivity disorders. A review of current and investigational drugs for their management. Pharm Ther 80(1):49–88

    Article  CAS  Google Scholar 

  27. 27.

    Dew MJ, Evans BK, Rhodes J (1984) Peppermint oil for the irritable bowel syndrome: A multicentre trial. Br J Clin Pract 38:394 –398

    PubMed  CAS  Google Scholar 

  28. 28.

    Rees WDW, Evans BK, Rhodes J (1979) Treating the irritable bowel syndrome with peppermint oil. Br Med J 2:835–836

    PubMed  CAS  Article  Google Scholar 

Download references

Acknowledgments

The authors would like to thank POUR SINA pharmaceutical company for providing Carmint and its placebo. This study originated at The Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

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Correspondence to Reyhaneh Vejdani.

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Vejdani, R., Shalmani, H.R.M., Mir-Fattahi, M. et al. The Efficacy of an Herbal Medicine, Carmint, on the Relief of Abdominal Pain and Bloating in Patients with Irritable Bowel Syndrome: A Pilot Study. Dig Dis Sci 51, 1501–1507 (2006). https://doi.org/10.1007/s10620-006-9079-3

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Keywords

  • Irritable bowel syndrome
  • Carmint
  • Herbal medicine
  • Randomized placebo-controlled trial