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Association Between Helicobacter pylori Infection and Cirrhosis in Patients with Chronic Hepatitis C Virus

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Abstract

We evaluated, employing a logistic regression model, the association between Helicobacter pylori infection and cirrhosis in a cohort of 106 patients (57 males; mean age, 52.9 years; range, 20–78 years) with chronic hepatitis C virus (HCV) from Rosario, Argentina. HCV was confirmed by ELISA and PCR. H. pylori status was determined by ELISA. Of the 106 patients evaluated, 47 (44.3%) had cirrhosis. A total of 70.2% (33/47) of cirrhotic patients and 47.5% (28/59) of noncirrhotic patients were H. pylori-positive. In univariate analyses, cirrhosis was associated with age (P = 0.016) and H. pylori-positive status (P = 0.019) but not with gender (P = 0.28) or length of infection (P = 0.35). In multivariate analysis, H. pylori infection (P = 0.037; OR = 2.42; 95% CI = 1.06–5.53) and age (P = 0.033; OR = 1.04; 95% CI = 1.00–1.07) of patients remained significant and independently associated with cirrhosis. In conclusion, our results demonstrate an association between H. pylori infection and cirrhosis in patients with hepatitis C virus.

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Authors and Affiliations

  1. Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte

    Dulciene Maria Magalhães Queiroz MD, Andreia Maria Camargos Rocha MD, Gifone Aguiar Rocha MD & Sarah Maria Singulano Cinque MD

  2. Faculdade de Medicina do Triângulo Mineiro, Brasil

    Adriana Gonçalves Oliveira PhD

  3. Servicio de Gastroenterologia del Hospital Centenario, Universidad Nacional de Rosario, Rosario, Argentina

    Alicia Godoy MD & Hugo Tanno MD

  4. Faculdade de Medicina da Universidade Federal de Minas Gerais, Av. Alfredo Balena, 190 sala 4026, 30130-100, Belo Horizonte, MG, Argentina

    Dulciene Maria Magalhães Queiroz MD

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  1. Dulciene Maria Magalhães Queiroz MD
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  2. Andreia Maria Camargos Rocha MD
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  3. Gifone Aguiar Rocha MD
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  4. Sarah Maria Singulano Cinque MD
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  5. Adriana Gonçalves Oliveira PhD
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  6. Alicia Godoy MD
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  7. Hugo Tanno MD
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Correspondence to Dulciene Maria Magalhães Queiroz MD.

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Queiroz, D.M.M., Rocha, A.M.C., Rocha, G.A. et al. Association Between Helicobacter pylori Infection and Cirrhosis in Patients with Chronic Hepatitis C Virus. Dig Dis Sci 51, 370–373 (2006). https://doi.org/10.1007/s10620-006-3150-y

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  • DOI: https://doi.org/10.1007/s10620-006-3150-y

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