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Clinical Response Is Associated with Elevated Plasma Interleukin-1 Receptor Antagonist During Selective Granulocyte and Monocyte Apheresis in Patients with Ulcerative Colitis

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Abstract

Depletion of granulocytes and monocytes (GM) by selective apheresis (GMA) with an Adacolumn exerts an anti-inflammatory effect in patients with ulcerative colitis (UC) or rheumatoid arthritis. However, the mechanism of the anti-inflammatory effect of GMA is not fully understood yet. We investigated the effect of GMA on the plasma concentration of interleukin-1 receptor antagonist (IL-1ra), a potent anti-inflammatory cytokine. Twenty-six patients with active UC received GMA at one session per week for 5 consecutive weeks. Clinical response was defined as Δclinical activity index (ΔCAI=CAI at entry – CAI at post)≥4, while clinical remission was defined as CAI≤4. Twenty-one of twenty-six patients (80.8%) responded to GMA. In the first session, plasma from responder patients showed a significant (P < 0.01) increase in IL-1ra in the Adacolumn outflow. In contrast, there was no change in IL-1ra in nonresponders. In conclusion, release of IL-1ra during GMA might be one mechanism of clinical efficacy associated with this therapy.

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Acknowledgment

The authors thank Mr. N. Shiobara of Japan Immunoresearch Laboratories for his technical support.

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Authors and Affiliations

  1. Department of Internal Medicine, Saitama Red Cross Hospital, Saitama, Japan

    Kyoya Sakimura

  2. Ageo Central General Hospital, Saitama, Japan

    Toshihide Omori

  3. Etsuro Iwashita Gastrointestinal Tract Clinic, Saitama, Japan

    Etsuro Iwashita

  4. Saitama Social Insurance Hospital, Saitama, Japan

    Takeshi Yoshida & Hiroo Anzai

  5. Second Department of Internal Medicine, National Defense Medical College, 3-2 Namik, Tokorozawa, 359-0042, Japan

    Yoshikazu Tsuzuki & Soichiro Miura

  6. Department of Gastroenterology and Hepatology, Saitama Medical School, Saitama, Japan

    Kenji Fujimori, Hiromichi Suzuki, Souichi Sugawara & Shinichi Ota

  7. Omiya Medical Center, Jichi Medical School, Omiya, Japan

    Fumio Konishi & Yukio Yoshida

  8. Japan Immunoresearch Laboratories, Takasaki, Japan

    Yuji Takeda, Katsuya Hiraishi, Abbi R. Saniabadi & Tatsuo Ide

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  1. Kyoya Sakimura
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Correspondence to Soichiro Miura.

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Sakimura, K., Omori, T., Iwashita, E. et al. Clinical Response Is Associated with Elevated Plasma Interleukin-1 Receptor Antagonist During Selective Granulocyte and Monocyte Apheresis in Patients with Ulcerative Colitis. Dig Dis Sci 51, 1525–1531 (2006). https://doi.org/10.1007/s10620-005-9012-1

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  • DOI: https://doi.org/10.1007/s10620-005-9012-1

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