Abstract
Curcumin, a natural compound used as a food additive, has been shown to have anti-inflammatory and antioxidant properties in cell culture and animal studies. A pure curcumin preparation was administered in an open label study to five patients with ulcerative proctitis and five with Crohn's disease. All proctitis patients improved, with reductions in concomitant medications in four, and four of five Crohn's disease patients had lowered CDAI scores and sedimentation rates. This encouraging pilot study suggests the need for double-blind placebo-controlled follow-up studies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ammon HPT, Wahl M: Pharmacology of Curcuma longa. Planta Med 57:1–7, 1991
Satoskar RR, Shah SJ, Shenoy SG: Evaluation of anti-inflammatory property of curcumin (diferuloytmethane) in patients with postoperative inflammation. Int J Pharmacol Ther Toxicol 24:651–654, 1986
Surh YJ: Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 40:1091–1097, 2002
Toda S, Miyase T, Aricht H, Tanizawa H, Takino Y: Natural antioxidant HI antioxidative components isolated from rhizome of curcuma longa. Chem Pharm Bull 33:1725–1728, 1985
Hanif R, Qiao L, Shiff SJ, Rigas B: Curcumin a natural plant phenolic food additive inhibits cell proliferation and induces ceil cycle changes in colon adenocarcinoma cell lines by prostaglandin-independent pathways. J Lab Clin Med 130:576–584, 1997
Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S, Howells L: Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signaling complex. Oncogene 18:6013–6020, 1999
Ranjan D, Chen C, Johnston TO, Reddy KS, Khan TT, Nagabhushan M: Curcumin inhibits mitogen stimulated lymphocyte proliferation NF-κB activation and IL-2 signaling. J Surg Res 114:272, 2003
Duvoix A, Morceau F, Deihalle S, Schmitz M, Schnekenburger M, Galteau MM, Dicato M, Diederichet M: Induction of apoptosis by curcumin: mediation by giutathione S transferase P1-1 inhibition. Biochem Pharmacol 66:1475–1483, 2003
Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, Jacobsen K: Curcumin attenuates DNB-induced murine colitis. Am J Physiol Gastrointest Liver Physiol 285:G235, 2003
Sugimoto K, Hanai H, Tozawa K, Aoshi T, Uchijima M, Nagata T, Koide Y: Curcumin prevents and ameliorates trinitrobenzene surfonic acide induced colitis in mice. Gastroenterology 123:1912–1922, 2002
Author information
Authors and Affiliations
Corresponding author
Additional information
Kindly provided by R. Kane Products, Pennsauken, New Jersey.
Rights and permissions
About this article
Cite this article
Holt, P.R., Katz, S. & Kirshoff, R. Curcumin Therapy in Inflammatory Bowel Disease: A Pilot Study. Dig Dis Sci 50, 2191–2193 (2005). https://doi.org/10.1007/s10620-005-3032-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10620-005-3032-8