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Determination of Plasma Trypsin-Like Activity in Healthy Subjects, Patients With Mild to Moderate Alcoholic Chronic Pancreatitis, and Patients With Nonjaundice Pancreatic Cancer

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Abstract

Trypsin-like activity is released after stimulation of the exocrine pancreas. We investigated under basal conditions and after stimulation by a meal whether patients suffering from pancreatic disorders differ with respect to plasma trypsin-like activity (PTLA).

In 45 subjects (healthy volunteers: n = 18, mild/moderate alcoholic chronic pancreatitis: n = 16, nonjaundice pancreatic cancer n = 7, and calcifying chronic pancreatitis: n = 4), basal and postprandial levels of PTLA were measured over a period of 2 hours.

Basal plasma levels were similar in the first 3 groups. After stimulation, healthy volunteers and patients with pancreatic cancer showed significant decreases in trypsin-like activity; however, plasma levels did not decrease in patients with mild/moderate chronic pancreatitis (P < .001).

Healthy individuals demonstrate a consistent decrease in postprandial trypsin-like plasma activity. This response is not altered in patients with pancreatic cancer, and it is not seen in patients with mild/moderate alcoholic chronic pancreatitis.

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Authors and Affiliations

  1. Servicio de Cirugía No 1, Hospital Nacional de Clínicas, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, República Argentina

    Carlos A. HernÁndez MD, Juan C. NicolÁs,  BiochD, JoaquÍn FernÁndez MD & Pedro Pizarro MD

  2. Avenida Fernando Fader 4442, 5009, Córdoba, República Argentina

    Carlos A. HernÁndez MD

Authors
  1. Carlos A. HernÁndez MD
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  2. Juan C. NicolÁs
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  3. BiochD
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  4. JoaquÍn FernÁndez MD
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  5. Pedro Pizarro MD
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Correspondence to Carlos A. HernÁndez MD.

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HernÁndez, C.A., NicolÁs, J.C., BiochD et al. Determination of Plasma Trypsin-Like Activity in Healthy Subjects, Patients With Mild to Moderate Alcoholic Chronic Pancreatitis, and Patients With Nonjaundice Pancreatic Cancer. Dig Dis Sci 50, 2165–2169 (2005). https://doi.org/10.1007/s10620-005-3026-6

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  • DOI: https://doi.org/10.1007/s10620-005-3026-6

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