Digestive Diseases and Sciences

, Volume 50, Issue 11, pp 2159–2162 | Cite as

Clonorchis sinensis-Associated Cholangiocarcinoma: A Case Report and Review of the Literature

  • Georgios I. Papachristou
  • Karen E. Schoedel
  • Ramesh Ramanathan
  • Mordechai RabinovitzEmail author
Case Report

Key Words

Clonorchis sinensis cholangiocarcinoma 


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  1. 1.
    International Agency for Research on Cancer: Infection with liver flukes (Opisthorchis viverrini, Opisthorchis felineus and Clonorchis sinensis). IARC Monogr Eval Carcinog Risks Hum 61:121'175, 1994Google Scholar
  2. 2.
    Sun T: Pathology and immunology of clonorchis sinensis infection in the liver. Ann Clin Lab Sci 14:208–215, 1984PubMedGoogle Scholar
  3. 3.
    Hou PC: The pathology of clonorchis sinensis infestation of the liver. J Pathol Bacteriol 70:53–64, 1955CrossRefPubMedGoogle Scholar
  4. 4.
    Schwartz DA: Cholangiocarcinoma associated with liver fluke infection: A preventable source of morbidity in Asian immigrants. Am J Gastroenterol 81:76–79, 1986PubMedGoogle Scholar
  5. 5.
    Liu LX, Harinasuta KT: Parasitic diseases of the liver and intestines: Liver and intestinal flukes. Gastroenterol Clin 25:627–636, 1996CrossRefGoogle Scholar
  6. 6.
    Woolf A, Green J, Levine JA, et al.: A clinical study of Laotian refugees infected with Clonorchis sinensis or Opisthorchis viverrini. Am J Trop Med Hyg 33:1279–1280, 1984PubMedGoogle Scholar
  7. 7.
    Choi TK, Wong KP, Wong J: Cholangiographic appearance in clonorchiasis. Br J Radiol 57:681–684, 1984PubMedGoogle Scholar
  8. 8.
    Sullivan WG, Koep LJ: Common bile duct obstruction and cholangiohepatitis in clonorchiasis. JAMA 243:2060–2061, 1980CrossRefPubMedGoogle Scholar
  9. 9.
    Shugar RA, Ryan JJ: Clonorchis sinensis and pancreatitis. Am J Gastroenterol 64:400–403, 1975PubMedGoogle Scholar
  10. 10.
    Hou PC: The relationship between primary carcinoma of the liver and infestation with Clonorchis sinensis. J Pathol Bacteriol 72:239–246, 1956CrossRefPubMedGoogle Scholar
  11. 11.
    Hou PC: Primary carcinoma of bile duct of the liver of the cat (Felis catus) infested with Clonorchis sinensis. J Pathol Bacteriol 87:239–244, 1964CrossRefPubMedGoogle Scholar
  12. 12.
    Bhamarapravati N, Viranuvatti V: Liver diseases in Thailand. Am J Gastroenterol 45:267–275, 1966PubMedGoogle Scholar
  13. 13.
    Chung CS, Lee SK: An epidemiological study of primary liver carcinomas in Pusan area with special reference to clonorchiasis. Korean J Pathol 10:33–64, 1976Google Scholar
  14. 14.
    Lee JH, Yang HM, Bak UB, et al.: Promoting role of Clonorchis sinensis infection on induction of cholangiocarcinoma during two-step carcinogenesis. Korean J Parasitol 32:13–17, 1994PubMedGoogle Scholar
  15. 15.
    Watanapa P, Watanapa WB: Liver fluke-associated cholangiocarcinoma. Br J Surg 89:962–970, 2002CrossRefPubMedGoogle Scholar
  16. 16.
    Williamson RCN, Rainey JB: The relationship between intestinal hyperplasia and carcinogenesis. Scand J Gastroenterol 19~(Suppl~104):57–76, 1984Google Scholar
  17. 17.
    Sher L, Iwatsuki S, Lebeau G, et al.: Hilar cholangiocarcinoma associated with clonorchiasis. Dig Dis Sci 34:1121–1123, 1989CrossRefPubMedGoogle Scholar
  18. 18.
    Ona FV, Dytoc JNO: Clonorchiasis-associated cholangiocarcinoma: A report of two cases with unusual manifestations. Gastroenterology 101:831–839, 1991PubMedGoogle Scholar

Copyright information

© Springer Science + Business Media, Inc. 2005

Authors and Affiliations

  • Georgios I. Papachristou
    • 1
  • Karen E. Schoedel
    • 2
  • Ramesh Ramanathan
    • 3
  • Mordechai Rabinovitz
    • 1
    • 4
    Email author
  1. 1.Departments of Medicine, Divisions of Gastroenterology and Hepatology, School of MedicineUniversity of PittsburghPittsburghUSA
  2. 2.Departments of Medicine, Divisions of Pathology, School of MedicineUniversity of PittsburghPittsburghUSA
  3. 3.Departments of Medicine, Pittsburgh Cancer Institute, School of MedicineUniversity of PittsburghPittsburghUSA
  4. 4.Center for Liver DiseasesPittsburghUSA

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