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Severe Cholestatic Liver Injury Days After Initiating Antiretroviral Therapy in a Patient with AIDS: Drug Toxicity or Immune Reconstitution Inflammatory Syndrome?

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References

  1. Palella FJ Jr, Delaney KM, Moorman AC, et al.: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 338:853–860, 1998

    Article  PubMed  Google Scholar 

  2. Sulkowski MS, Thomas DL, Chaisson RE, Moore RD: Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection. JAMA 283:74–80, 2000

    Article  PubMed  Google Scholar 

  3. den Brinker M, Wit FW, Wertheim-van Dillen PM, et al.: Hepatitis B and C virus co-infection and the risk for hepatotoxicity of highly active antiretroviral therapy in HIV-1 infection. AIDS 14:2895–2902, 2000

    Article  PubMed  Google Scholar 

  4. Nunez M, Lana R, Mendoza JL, Martin-Carbonero L, Soriano V: Risk factors for severe hepatic injury after introduction of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 27:426–431, 2001

    PubMed  Google Scholar 

  5. Martinez E, Blanco JL, Arnaiz JA, et al.: Hepatotoxicity in HIV-1-infected patients receiving nevirapine-containing antiretroviral therapy. AIDS 15:1261–1268, 2001

    Article  PubMed  Google Scholar 

  6. Wit FW, Weverling GJ, Weel J, Jurriaans S, Lange JM: Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy. J Infect Dis 186:23–31, 2002

    Article  PubMed  Google Scholar 

  7. Sulkowski MS, Thomas DL, Mehta SH, Chaisson RE, Moore RD: Hepatotoxicity associated with nevirapine or efavirenz-containing antiretroviral therapy: role of hepatitis C and B infections. Hepatology 35:182–189, 2002

    Article  PubMed  Google Scholar 

  8. Zaman F, Gang Y, Kenneth DA, Shahnila L, Ziban GB: Successful orthotopic liver transplantation after trimethoprim-sulfamethoxazole associated fulminant liver failure. Clin Transplant 17(5):461–464, 2003

    Article  PubMed  Google Scholar 

  9. Ilario MJM, Ruiz JE, Axiotis CA: Acute fulminant hepatic failure in a woman treated with phenytoin and trimethoprim-sulfamethoxazole. Arch Pathol Lab Med. 124(12):1800–1803, 2000

    PubMed  Google Scholar 

  10. DeSimone JA, Pomerantz RJ, Babinchak TJ: Inflammatory reactions in HIV-1 infected persons after initiation of highly active antiretroviral therapy. Ann Intern Med 133:447–454, 2000

    PubMed  Google Scholar 

  11. Desimone JA, Babinchak TJ, Kaulback KR, Pomerantz: Treatment of Mycobacterium avium complex immune reconstitution disease in HIV-1-infected individuals. AIDS Patient Care STDS17(12):617–622, 2003

    Article  Google Scholar 

  12. French MA, Lenzo N, John M, et al.: Immune restoration disease after the treatment of immunodeficient HIV-patients with highly active antirertoviral therapy. HIV Med 1:107–115, 2000

    Article  PubMed  Google Scholar 

  13. Phillips P, Kwiatkowski MB, Copland M, Craib K, Monaner J: Mycobacterial lymphadenitis associated with the initiation of combination antiretroviral therapy. J AIDS 20:1222–1228, 1999

    Google Scholar 

  14. Race EM, Adelson-Mitty J, Kriegel GR, et al.: Focal mycobacterial lymphadenitis following initiation of protease-inhibitor therapy in patients with advanced HIV-1 disease. Lancet 351:252–255, 1998

    Article  PubMed  Google Scholar 

  15. Packer SJ, Cesario T, Williams JH: Mycobacterium avium complex infection presenting as endobronchial lesions in immunosuppressed patients. Ann Intern Med 109:389–393, 1998

    Google Scholar 

  16. Manegold C, Hannoun C, Wywiol A, et al.: Reactivation of hepatitis B virus replication accompanied by acute hepatitis in patients receiving highly active antiretroviral therapy. Clin Infect Dis 32:144–148, 2001

    Article  PubMed  Google Scholar 

  17. Benhamou Y, Di MV, Bochet M, et al.: Factors affecting liver fibrosis in human immunodeficiency virus- and hepatitis C virus-co infected patients: impact of protease inhibitor therapy. Hepatology 34:283–287, 200

  18. John M, Flexman J, French MAH: Hepatitis C virus-associated hepatitis following treatment of HIV-infected patients with HIV protease inhibitors: an immune restoration disease?. AIDS 12:2289–2293, 1998

    Article  PubMed  Google Scholar 

  19. Foudraine NA, Hovenkamp E, Notermans DW, et al.: Immunopathy as a result of highly active antiretroviral therapy in HIV-1 infected patients. AIDS 13:177–184, 1999

    Article  PubMed  Google Scholar 

  20. Woods M, MacGinley R, Eisen D, Allworth A: HIV combination therapy: Partial immune restitution unmasking latent cryptococcal infection. AIDS 12:1491–1494, 1998

    Article  PubMed  Google Scholar 

  21. Rutschmann OT, Negro F, Hirschel B, Hadengue A, Anwar D, Perrin LH: Impact of treatment with human immunodeficiency virus (HIV) protease inhibitors on hepatitis C viremia in patients with coinfected with HIV. J Infect Dis 177:783–785, 1998

    PubMed  Google Scholar 

  22. French MA, Mallal SA, Dawkins RL: Zidovudine-induced restoration of cell-mediated immunity to mycobacteria in immunodeficient HIV-infected patients. AIDS 6:1293–1297, 1992

    PubMed  Google Scholar 

  23. Cooney EL: Clinical indicators of immune restoration following highly active antiretroviral therapy. Clin Infect Dis 34:224–233, 2002

    Article  PubMed  Google Scholar 

  24. Abrescia N, D'Abbraccio M, Figoni M, Busto A, Butrico E, De Marco M, Viglietti R: Fulminant hepatic failure after the start of an efavirenz-based HAART regimen in a treatment naïve patient female AIDS patient without hepatitis virus co-infection. J Antimicrob Chemother 50(5):763–765, 2002

    Article  PubMed  Google Scholar 

  25. Gaya DR, Thorburn D, Oien KA, Morris AJ, Stanley AJ: Hepatic granulomas: a 10-year single centre experience. J Clin Pathol 56(11):850–853, 2003

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Divisions of Gastrointestinal and Liver Diseases, University of Southern California, Los Angeles, California, USA

    Sumita Verma, Hetal Bhakta, Arash Nowain & Shireen Pais

  2. Divisions of Pathology, University of Southern California, Los Angeles, California, USA

    Gary Kanel

  3. Divisions of Infectious Diseases, University of Southern California, Los Angeles, California, USA

    Kathleen Squires

  4. University of Southern California, Keck School of Medicine, Hepatitis Research and Treatment Centre, 1640 Marengo Street, Suite 103, Los Angeles, California, 90033, USA

    Sumita Verma

Authors
  1. Sumita Verma
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  2. Hetal Bhakta
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  3. Arash Nowain
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  4. Shireen Pais
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  5. Gary Kanel
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  6. Kathleen Squires
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Correspondence to Sumita Verma.

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Verma, S., Bhakta, H., Nowain, A. et al. Severe Cholestatic Liver Injury Days After Initiating Antiretroviral Therapy in a Patient with AIDS: Drug Toxicity or Immune Reconstitution Inflammatory Syndrome?. Dig Dis Sci 50, 1813–1817 (2005). https://doi.org/10.1007/s10620-005-2943-8

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  • DOI: https://doi.org/10.1007/s10620-005-2943-8

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