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The Relation Between NOD2/CARD15 Mutations and the Prevalence and Phenotypic Heterogeneity of Crohn’s Disease: Lessons from the Israeli Arab Crohn’s Disease Cohort

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Abstract

The prevalence of Crohn’s disease depends on geographic location and racial background. Arg702Trp, Gly908Arg, and Leu1007fsinsC mutations in the NOD2/CARD15 gene are associated with Crohn’s disease in Caucasians. The mutation rate among Israeli Jewish patients is 27%–41%. The prevalence of Crohn’s disease is much lower in the Israeli Arab compared to the Israeli Jewish population. We studied the NOD2/CARD15 mutation rate and disease phenotype (according to the Vienna classification) among the Israeli Arabs and compared them with those in an Israeli Jewish cohort. We recruited 66 Israeli Arab patients and 122 ethnically matched controls. Five patients (8.2%) and three controls (2.3%) carried one NOD2/CARD15 mutation. The phenotypic characteristics of the Arab and Jewish patients were very similar. We conclude that NOD2/CARD15 mutations do not contribute to Crohn’s susceptibility in the Israeli Arab population and suggest that NOD2/CARD15 mutations have an important effect on Crohn’s prevalence within a specific population but not on the phenotype.

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Authors and Affiliations

  1. Department of Gastroenterology, Rambam Medical Center, Haifa

    Amir Karban MD, Oren Atia MD, Shula Nesher MD & Rami Eliakim MD

  2. Departments of Medicine, Hadassah University Hospital, Jerusalem

    Eran Leitersdorf MD

  3. Departments of Internal Medicine, Hadassah University Hospital, Jerusalem

    Zvi Ackerman MD

  4. Liver Unit, Hadassah University Hospital, Jerusalem

    Rifaat Safadi MD

  5. Gastroenterology Unit, Central Hospital of the Emek, Afula

    Azmi Shahbari MD

  6. Department of Gastroenterology, Western Galilee Hospital, Nahariya

    Wisam Sbeit MD

  7. Gastroenterology Unit, Poriah Hospital, Tveria

    Rawia Mualem MD

  8. Pediatric Gastroenterology Unit, E. Wolfson Medical Center, Holon, Israel

    Arie Levine MD

  9. Gastroenterology Department, Rambam Medical Center, Haifa, Israel

    Amir Karban MD

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  1. Amir Karban MD
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Correspondence to Amir Karban MD.

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R. Safadi, MD, and R. Eliakim, MD, share senior authorship

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Karban, A., Atia, O., Leitersdorf, E. et al. The Relation Between NOD2/CARD15 Mutations and the Prevalence and Phenotypic Heterogeneity of Crohn’s Disease: Lessons from the Israeli Arab Crohn’s Disease Cohort. Dig Dis Sci 50, 1692–1697 (2005). https://doi.org/10.1007/s10620-005-2917-x

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  • DOI: https://doi.org/10.1007/s10620-005-2917-x

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