Skip to main content

Advertisement

SpringerLink
Log in

The Relationship of ABO Blood Group, Age, Gender, Smoking, and Helicobacter pylori Infection

  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

It is well known that blood group antigens are related to the development of peptic ulcer and gastric carcinoma. This study sought to determine the relationship between H. pylori and ABO/Rhesus blood groups, age, gender, and smoking. Patients (335 women and 205 men; mean age, 51.68 ± 15.0 years; range, 18–85 years) who attended our outpatient clinic were enrolled in the study. All patients were randomly selected in each age group. Demographic data recorded for each patient included age, gender, and tobacco use. Blood samples were tested for H. pylori antibodies, and ABO/Rhesus blood group antigen typing was performed. Serum antibodies were tested against H. pylori infection. Prevalences of all blood groups were O (29.2%), A (38.2%), B (17.8%), and AB (14.8%). As expected from previous studies, we found that seropositivity for H. pylori increased with age. H. pylori Ig G antibody positivity was detected in 185 of 335 women (60.6%), compared with 88 of 205 men (42.9%), a statistically significant difference (P < 0.05). H. pylori Ig G antibody positivity was detected in 206 of 379 nonsmokers (54.3%) compared with 67 of 161 smokers (41.6%), a statistically significant difference (P < 0.05). Patients in blood groups A and O were more prone to H. pylori infection than were patients in other blood groups (P < 0.05), and patients in the AB blood group were less prone to H. pylori infection compared with patients in other blood groups (P < 0.05). The results of this study demonstrate that H. pylori infection can be related to ABO blood group, age, gender, and smoking.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Megraud F: Eidemiology of Helicobacter pylori infection. Gastroenterol Clin North Am 22:73–88, 1993

    PubMed  Google Scholar 

  2. Sitas F, Forman D, Yarnell JWG, et al.: Helicobacter pylori infection rates in relation to age and social class in a population of Welsh men. Gut 32:25–28, 1991

    PubMed  Google Scholar 

  3. Graham DY, Malaty HM, Evans DG, et al.: Epidemiology of Helicobacter pylori in asymptomatic population in the United States. Gastroenterology 100:495–501, 1991

    Google Scholar 

  4. Armstrong JA, McGechie DB, Glancy RJ: Campylobacter infection and gastroduodenal disease. Med J Aust 142:436–439, 1985

    PubMed  Google Scholar 

  5. Rathbone BJ, Heatley RV: Campylobacter pylori: a new factor in peptic ulcer disease. Gut 27:635–641, 1986

    PubMed  Google Scholar 

  6. Rauws EA, Tygat GN: Cure of duodenal ulcer associated with eradication of helicobacter pylori. Lancet 1:1233–1235, 1990

    Google Scholar 

  7. Macarthur C, Saunders N, Feldman W: Helicobacter pylori, gastroduodenal disease and recurrent abdominal pain in children. JAMA 273:729–734, 1995

    PubMed  Google Scholar 

  8. Wotherspoon AC: Gastric lymphoma of mucosa associated lymphoid tissue and Helicobacter pylori. Annu Rev Med 49:289–299, 1998

    PubMed  Google Scholar 

  9. Wu TC, Chen LK, Lai CR: Primary gastric lymphoma associated with helicobacter pylori in a child. J Ped Gastroenterol Nutr 32:608–610, 2001

    Google Scholar 

  10. Aydin A, Ersoz G, Ozutemiz A, Tuncyurek M: Low reinfection rate of Helicobacter pylori infection in Turkey. J Clin Gastroenterol 30:337, 2000

    Google Scholar 

  11. Smith A, Athison S, Power E, Abdulla Y: Blood group antigens and Helicobacter pylori infections. Lancet 1994;343:543, 1994

    Google Scholar 

  12. Clark CA, Wyn EJ, Haddock DRW, Howel, Evans AW, McConnell RB, Sheppard PM: ABO blood groups and secretor character in duodenal ulcer. Br Med J 1956;2:725–731, 1956

    Google Scholar 

  13. Mentis A, Blackwell CC, Weir DM, Spiliadis C, Dailianas A, Skandalis N: ABO blood groups, secretor status, and detection of helicobacter pylori among patients with gastric or duodenal ulcer. Epidemiol Infect 106:221, 1991

    PubMed  Google Scholar 

  14. Boren T, Falk, Roth K, Larson G, Normark S: Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigens. Science 262:1892–1895, 1993

    PubMed  Google Scholar 

  15. Vaira D, Holton J, Miglioli M, et al.: Peptic ulcer disedase and Helicobacter pylori infection. Curr Opin Gastroenterol 10:98–104, 1994

    Google Scholar 

  16. Blaser MJ, Chyou PH, Nomura A: Age at establishment of helicobacter pylori infection and gastric carcinoma, gastric ulcer and duodenal ulcer risk. Cancer Res 55:562–565, 1995

    PubMed  Google Scholar 

  17. The Eurogast Study Group: An international association between Helicobacter pylori infection and gastric cancer. Lancet 1:1359–1362, 1993

    Google Scholar 

  18. Mourant AE, Kopec AC, Domaniewska-Sobczak K: The Distribution of the Human Blood Groups and Other Polymorphisms. London, Oxford University Press, 1976

  19. Mourant AE, Kopec AC, Domaniewska-Sobczak K: Blood Groups and Diseases: A Study of Associations of Diseases with Blood Groups and Other Polymorphisms. London, Oxford University Press, 1978

    Google Scholar 

  20. Clarke CA, Edwards JW, Haddock DRW, et al.: ABO blood groups and secretor character in duodenal ulcer. BMJ 2:725–31, 1956

    Google Scholar 

  21. Clark CA, Evand DAP, McConnell RB, Sheppard M: Secretion of blood group antigens and peptic ulcer. BMJ 1:603–607, 1959

    Google Scholar 

  22. Atherton JC, Tham KT, Peek RM, Cover TL, Blaser MJ: Density of helicobacter pylori infection in vivo as assed by quantitative culture and histology. J Infect Dis 1174:552–556, 1996

    Google Scholar 

  23. Loffeld RJ, Stobberingh E: Helicobacter pylori and ABO blood groups. J Clin Pathol 44:516–517, 1991

    PubMed  Google Scholar 

  24. Niv Y, Fraser G, Delpre G, Neeman A, Leiser A, Samra Z: Helicobacter pylori and ABO blood groups. Am J Gastroenterol 91:101–104, 1996

    PubMed  Google Scholar 

  25. Aird I, Bentall HH, Roberts JAF: A relationship between cancer of stomach and the ABO blood groups. BMJ 1:799–801, 1953

    PubMed  Google Scholar 

  26. Alkout AM, Blackwell CC, Weir DM, et al.: Isolation of a cell surface comonent of Helicobacter pylori that binds H type 2, Lewis a and Lewis b antigens. Gastroenterology 112:1179–1187, 1997

    PubMed  Google Scholar 

  27. Atherton JC, Tham KT, Peek RM, Cover TL, Blaser MJ. Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J Infect DÝS 1996;174:552–6.

    Google Scholar 

  28. Habbick BF, Melrose AC, Grant JC. Duodenal ulcer in childhood. Arch Dis Child 1968;43:23–7.

    PubMed  Google Scholar 

  29. Nijevitch A, Khamidullina SLL: Childhood duodenal ulcer associated with Helicobacter pylori and ABO blood groups. Am J Gastroenterol 94:1424–1425, 1999

    PubMed  Google Scholar 

  30. The Eurogast Study Group: Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. Gut 34:1672–1676, 1993

    Google Scholar 

  31. Wu CT, Chen LK, Hwang SJ: Seroprevalence of Helicobacter pylori in school–aged Chinese in Tapei City and relationship between ABO blood groups. World J Gastroenterol 9:1752–1755, 2003

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Baskent University Faculty of Medicine, Fevzi Cakmak Caddesi, 10 Sokak, No. 45, Bahcelievler, 06490, Ankara, Turkey

    Mehmet Kanbay MD

  2. Department of Gastroenterology, Baskent University Faculty of Medicine, Fevzi Cakmak Caddesi, 10 Sokak, No. 45, Bahcelievler, 06490, Ankara, Turkey

    Gürden Gür MD, Ugur Yilmaz MD & Sedat Boyacioĝlu MD

  3. Department of Infectious Disease, Baskent University Faculty of Medicine, Fevzi Cakmak Caddesi, 10 Sokak, No. 45, Bahcelievler, 06490, Ankara, Turkey

    Hande Arslan MD

  4. 35 Sokak, 81/5, Bahcelievler, 06490, Ankara, Turkey

    Mehmet Kanbay MD

Authors
  1. Mehmet Kanbay MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gürden Gür MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hande Arslan MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ugur Yilmaz MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sedat Boyacioĝlu MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mehmet Kanbay MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kanbay, M., Gür, G., Arslan, H. et al. The Relationship of ABO Blood Group, Age, Gender, Smoking, and Helicobacter pylori Infection. Dig Dis Sci 50, 1214–1217 (2005). https://doi.org/10.1007/s10620-005-2762-y

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10620-005-2762-y

Key Words

Search

Navigation