Abstract
Twenty-two patients (13 men and 9 women; median age, 34 years; range, 15–64 years) with ulcerative colitis (UC) were evaluated to determine the incidence of acute pancreatitis with UC at the First Department of Internal Medicine, Mie University School of Medicine, during 1989–2001. Among these, three patients (14%) were diagnosed as having had episodes of acute pancreatitis during the mean follow-up period of 6 years. One patient presented with acute pancreatitis and UC simultaneously. Two patients had drug-induced pancreatitis (one due to azathioprine and the other due to 5-ASA). In conclusion, acute pancreatitis is not a frequent, but an occasional extraintestinal manifestation of UC.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Refrences
Greenstein AJ, Janowitz HD, Sachar DB: The extra-intestinal complications of Crohn’s disease and UC: a study of 700 patients. Medicine 55:401–412, 1976
Rankin GB, Watts HD, Melnyk CS, Kelley ML Jr: National cooperative Crohn’s disease study: extraintestinal manifestations and perianal complications. Gastroenterology 77:914–920, 1979
Ball WP, Baggenstoss AH, Bargen JA: Pancreatic lesions associated with chronic UC. Arch Pathol 50:345–358, 1950
Seyrig JA, Jian R, Modigliani R, Golfain D, Florent C, Messing B, Bitoun A: Idiopathic pancreatitis as associated with IBD. Dig Dis Sci 30:1121–1126, 1985
Axon ATR, Ashton MG, Lintott DJ: Chronic pancreatitis and IBD. Clin Radiol 30:179–182, 1979
Forbes D, Scott RB, Trevenen C, Hershfield N, Gall DG: Chronic pancreatitis associated with UC. Clin Invest Med 10:321–324, 1987
Lysy J, Goldin E: Pancreatitis in UC. J Clin Gastroenterol 15:336–339, 1992
Mallory A, Kern F Jr: Drug-induced pancreatitis: a critical review. Gastroenterology 78:813–820, 1980
Lankish PG, Droge M, Gottesleben F: Drug induced acute pancreatitis: Incidence and severity. Gut 37:565–567, 1995
Heikius B, Niemela S, Lehtola J, Karttunen TJ: Elevated pancreatic enzymes in IBD are associated with extensive disease. Am J Gastroenterol 94:1062–1069, 1999
Gurian LE, Keefe EB Pancreatic insufficiency associated with UC and pericholangitis. Gastroenterology 82:581–585, 1982
Epstein O, Chapman RWG, Lake-Bakaar G, Foo AY, Rosalki SB, Sherlock S: The pancreas in primary biliary cirrhosis and primary sclerosing cholangitis. Gastroenterology 83:1177–1182, 1982
Borkje B, Vetvik K, Odegaard S, Schrumpf E, Larssen TB, Kolmannskog F: Chronic pancreatitis in patients with sclerosing cholangitis and UC. Scand J Gastroenterol 20:539–542, 1985
Schrumpf E, Fausa O, Forre O, Dobloug JH, Ritland S, Thorsby E: HLA antigens and immunoregulatory T cells in UC associated with hepatobiliary disease. Scand J Gastroenterol 17:187–191, 1982
Sturdevant RAL, Singleton JW, Deren JJ, Law DH, Mccleery JL: Azathioprine-related pancreatitis in patients with Crohn’s disease. Gastroenterorology 77:883–886, 1979
Sachedina B, Saibil F, Cohen LB, Whittey J: Acute pancreatitis due to 5-aminosalicylate. Ann Intern Med 110:490–492, 1989
Deprez P, Descamps CH, Fiasse R: Pancreatitis induced by 5-aminosalicylic acid. Lancet 2:445–446, 1989
Adachi E, Okazaki K, Matsushima Y, Seno H, Uchida K, Nakase H, Kawanami C, Nakamura T, Chiba T: Acute pancreatitis secondary to 5-aminosalicylic acid therapy in a patient with UC. Int J Pancreatol 25:217–221, 1999
Fernandez J, Sala M, Panes J, Feu F, Navarro S, Teres J: Acute pancreatitis after long-term 5-aminosalicylic acid therapy. Am J Gastroenterol 92:2302–2303, 1997
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Inoue, H., Shiraki, K., Okano, H. et al. Acute Pancreatitis in Patients with Ulcerative Colitis. Dig Dis Sci 50, 1064–1067 (2005). https://doi.org/10.1007/s10620-005-2705-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10620-005-2705-7