Data Mining and Knowledge Discovery

, Volume 29, Issue 3, pp 765–791 | Cite as

Evolutionary soft co-clustering: formulations, algorithms, and applications

  • Wenlu Zhang
  • Rongjian Li
  • Daming Feng
  • Andrey Chernikov
  • Nikos Chrisochoides
  • Christopher Osgood
  • Shuiwang Ji
Article

Abstract

We consider the co-clustering of time-varying data using evolutionary co-clustering methods. Existing approaches are based on the spectral learning framework, thus lacking a probabilistic interpretation. We overcome this limitation by developing a probabilistic model in this paper. The proposed model assumes that the observed data are generated via a two-step process that depends on the historic co-clusters. This allows us to capture the temporal smoothness in a probabilistically principled manner. To perform maximum likelihood parameter estimation, we present an EM-based algorithm. We also establish the convergence of the proposed EM algorithm. An appealing feature of the proposed model is that it leads to soft co-clustering assignments naturally. We evaluate the proposed method on both synthetic and real-world data sets. Experimental results show that our method consistently outperforms prior approaches based on spectral method. To fully exploit the real-world impact of our methods, we further perform a systematic application study on the analysis of Drosophila gene expression pattern images. We encode the spatial gene expression information at a particular developmental time point into a data matrix using a mesh-generation pipeline. We then co-cluster the embryonic domains and the genes simultaneously for multiple time points using our evolutionary co-clustering method. Results show that the co-clusters of gene and embryonic domains reflect the underlying biology.

Keywords

Evolutionary co-clustering Expectation maximization  Biological image computing Bioinformatics 

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Copyright information

© The Author(s) 2014

Authors and Affiliations

  • Wenlu Zhang
    • 1
  • Rongjian Li
    • 1
  • Daming Feng
    • 1
  • Andrey Chernikov
    • 1
  • Nikos Chrisochoides
    • 1
  • Christopher Osgood
    • 2
  • Shuiwang Ji
    • 1
  1. 1.Department of Computer ScienceOld Dominion UniversityNorfolkUSA
  2. 2.Department of Biological SciencesOld Dominion UniversityNorfolkUSA

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