, Volume 70, Issue 2, pp 793–806 | Cite as

Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes

  • Hui Jiang
  • Huishan Wang
  • Tao Liu
  • Zhonglu Yang
  • Renteng Zhang
  • Hongguang Han
Original Article


Recently, the incidence of myocardial infarction has been increasing annually. Now cell therapy is a major new strategy in the treatment of this public health challenge. Most recently, evidences showed that MSCs can reduce the area of infarction and improve the heart function. In our study we found that MSCs could promote cardiomyocytes proliferation, inhibit the apoptosis of cardiomyocytes and promote cardiomyocytes autophagy function. These functions could be a therapeutic effect on myocardial infarction. At the same time, we first revealed that MSCs may achieve these functions by the activation of VEGF signaling pathways.


Cardiomyocytes MSCs Myocardial infarction 



Marrow mesenchyme stem cells


Left ventricular


Vascular endothelial growth factor

SD rat

Sprague-Dawley rats


Dulbecco’s Modified Eagle’s medium


Fetal bovine serum


Phosphate buffer saline


3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide




Reactive oxygen species


Flow cytometry assay



Thanks the care and support of all colleagues.

Authors’ Contribution

HJ: conceived of the study, carried out the molecular studies. HW: carried out the molecular studies, helped to draft the manuscript. TL: participated in the design of the study and performed the statistical analysis. ZY: participated in its design and coordination and helped to draft the manuscript. RZ: conceived of the study. HH: conceived of the study.


This research was sponsored by the Science and Technology Project of Liaoning Province (2013225089).

Compliance with ethical standards

Conflict of interest

No conflicts of interest. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Ethical approval

Animal study received China medical university animal care and use committee approval.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Hui Jiang
    • 1
  • Huishan Wang
    • 1
  • Tao Liu
    • 1
  • Zhonglu Yang
    • 1
  • Renteng Zhang
    • 1
  • Hongguang Han
    • 1
  1. 1.Department of Cardiovascular SurgeryThe General Hospital of Shenyang Military RegionShenyangPeople’s Republic of China

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