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Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells

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Abstract

An intravenous injection of plasma-derived immunoglobulins is used for the treatment of severe infectious and autoimmune disorders. Despite of its clinical efficacy, precise mechanisms by which intravenous immunoglobulin (IVIg) suppresses proinflammatory immune response are still enigmatic. Here, we provide in vitro evidence that IVIg inhibits homeostatic proliferation of B cells accompanied by induction of their cell aggregation. The IVIg-driven suppression of B cell proliferation and induction of cell aggregation are both unaffected by treatment with a neutralizing antibody against low-affinity Fc receptors for IgG (CD16/FcγRIII and CD32/FcγRII), known cell surface ligands for IVIg. Our observations propose a new immunosuppressive action of IVIg, which directly acts on steady-state B cells to suppress their homeostatic expansion.

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Author notes

  1. Ayane Hori and Takashi Fujimura equally contributed to this work.

Authors and Affiliations

  1. Hiroshima Research Center for Healthy Aging (HiHA), Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima, 739-8530, Japan

    Ayane Hori, Takashi Fujimura & Seiji Kawamoto

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  1. Ayane Hori
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  2. Takashi Fujimura
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  3. Seiji Kawamoto
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Correspondence to Takashi Fujimura or Seiji Kawamoto.

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The authors declare that there is no conflict of interest regarding this study.

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Hori, A., Fujimura, T. & Kawamoto, S. Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells. Cytotechnology 70, 921–927 (2018). https://doi.org/10.1007/s10616-017-0176-2

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