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Cytotechnology

, Volume 70, Issue 2, pp 593–601 | Cite as

Mangiferin inhibits cell migration and invasion through Rac1/WAVE2 signalling in breast cancer

  • Qing Deng
  • Yan-Xiao Tian
  • JianJun Liang
Original Article
  • 153 Downloads

Abstract

Breast tumour progression results from the advancement of the disease to a metastatic phenotype. Rac1 and Cdc42 belong to the Rho family of genes that, together with their downstream effectors, Wiskott–Aldrich Syndrome protein-family verprolin-homologous protein 2 (WAVE2) and Arp2/3, assume a vital part in cytoskeletal rearrangement and the arrangement of film projections that advance malignant cell relocation and invasion. Mangiferin is a characteristic polyphenolic compound from Mangifera indica L. (Anacardiaceae), ordinarily referred to as mango, that is consumed worldwide as a natural product, including culinary and seasoning applications. Mangiferin delays breast malignancy development and progression by inhibiting different signalling pathways required in mitogenic signalling and metastatic progression. Studies were performed to analyse the impact of mangiferin on Rac1/WAVE2 flagging, relocation and invasion in highly metastatic human MDA-MB-231 mammary cells. Additional studies led to the observation that comparative treatment with mangiferin caused marked reduction in tumour cell movement and invasion. Taken together, these discoveries demonstrate that mangiferin treatment adequately hinders Rac1/WAVE2 flagging and diminishes metastatic phenotypic expression in malignant mammary cells, indicating that mangiferin may provide a benefit as a novel restorative approach in the treatment of metastatic breast cancer.

Keywords

Migration Invasion Mangiferin Rac1 Wiskott–Aldrich Syndrome protein-family verprolin-homologous protein 2 (WAVE2) 

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Copyright information

© Springer Science+Business Media B.V. 2018

Authors and Affiliations

  1. 1.Department of PathologyThe First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and TechnologyLuoyangChina
  2. 2.Department of Emergency MedicineSan Er Ling Yi HospitalHanzhong CityChina

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