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Assessment of the antimicrobial, antioxidant and cytotoxic activities of the wild edible mushroom Agaricus lanipes (F.H. Møller & Jul. Schäff.) Hlaváček

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Abstract

The present investigation was undertaken to evaluate the antimicrobial and antioxidant activities of the wild edible mushroom Agaricus lanipes, and also to investigate its cytotoxicity and potential and possible apoptotic effect against the A549 lung cancer cell line in in vitro conditions. Total antioxidant capacity, total phenolic content, total oxidant status, total antioxidant status, lipid hydroperoxides, and total free –SH levels of A. lanipes were found to be 4.55 mg T/g, 14.6 mg GA equivalent/g, 3.10 mg H2O2 equivalent/g, 2.25 mg H2O2 equivalent/g, and 1.90 µmol/g, respectively. The methanolic extract of A. lanipes had relatively strong antimicrobial activity against seven tested microorganism strains. It also had high anti-proliferative potency and strong pro-apoptotic effects, and this mushroom used as a daily nutrient could be a source for new drug developments and treatment in cancer therapies, and could be a guide for studies in this area.

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Acknowledgements

The authors would like to acknowledge the financial support of the Pamukkale University Scientific Research Projects Coordination Unit (PAUBAP) (Project Numbers: 2010FBE086 and 2013KRM008).

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Authors and Affiliations

  1. Department of Biology, Faculty of Science and Arts, Pamukkale University, P.O. BOX 20001, Denizli, Turkey

    Oğuzhan Kaygusuz & Kutret Gezer

  2. Denizli Vocational School of Technical Sciences, Pamukkale University, Denizli, Turkey

    Meruyert Kaygusuz

  3. Department of Medical Biology, Faculty of Medicine, Pamukkale University, Denizli, Turkey

    Yavuz Dodurga & Mücahit Seçme

  4. Department of Food Engineering, Engineering Faculty, Pamukkale University, Denizli, Turkey

    Emine Nur Herken

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  1. Oğuzhan Kaygusuz
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  2. Meruyert Kaygusuz
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  3. Yavuz Dodurga
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  4. Mücahit Seçme
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  5. Emine Nur Herken
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  6. Kutret Gezer
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Correspondence to Oğuzhan Kaygusuz.

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Kaygusuz, O., Kaygusuz, M., Dodurga, Y. et al. Assessment of the antimicrobial, antioxidant and cytotoxic activities of the wild edible mushroom Agaricus lanipes (F.H. Møller & Jul. Schäff.) Hlaváček. Cytotechnology 69, 135–144 (2017). https://doi.org/10.1007/s10616-016-0045-4

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  • DOI: https://doi.org/10.1007/s10616-016-0045-4

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