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Cytotoxic effects of 4-octylphenol on fish hepatocytes

Cytotechnology volume 68, pages 1577–1583 (2016)Cite this article

An Erratum to this article was published on 24 October 2015

Abstract

The present study was conducted to determine cytotoxic effects of 4-octylphenol (4-OP) on primary cultured hepatocytes of pearl mullet (Alburnus tarichi). Lactate dehydrogenase (LDH) release, malondialdehyde (MDA) level, antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-S-transferase (GST)] and glutathione (GSH) content were measured after 24-h exposure to 4-OP. 4-OP caused dose- and time-dependent increases in LDH release. Significant induction of MDA level and decrease in GSH content were found. SOD and GPx activities were decreased while GST activity was increased. These findings suggest that 4-OP leads to cytotoxicity by depressing antioxidant defenses in fish hepatocytes.

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Acknowledgments

The author wishes to thank Dr. Ertuğrul Kankaya, and research assistant Hüseyin Eroğlu for their help during fish sampling. Special thanks to Gurbet Ceylan Kaptaner for her support during the study.

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  1. Department of Biology, Faculty of Science, Yüzüncü Yıl University, 65080, Van, Turkey

    Burak Kaptaner

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  1. Burak Kaptaner
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Correspondence to Burak Kaptaner.

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Kaptaner, B. Cytotoxic effects of 4-octylphenol on fish hepatocytes. Cytotechnology 68, 1577–1583 (2016). https://doi.org/10.1007/s10616-015-9916-3

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  • DOI: https://doi.org/10.1007/s10616-015-9916-3

Keywords

  • 4-Octylphenol
  • Cytotoxicity
  • Antioxidant defenses
  • Isolated fish hepatocytes
  • Alburnus tarichi