, Volume 68, Issue 2, pp 261–266 | Cite as

Evaluation of maternal and embryotoxic effects following the treatment of chloral hydrate in Drosophila melanogaster

  • Arif Ayar
  • Deniz Altun ÇolakEmail author
  • Handan Uysal
Original Research


Chloral hydrate (CH) is commonly used as a sedative and a hypnotic in pediatric medicine. In this study, the effects of CH on various developmental stages of Drosophila melanogaster were investigated. Different concentrations of CH (0.1; 0.3; 0.5 and 1 mg/mL) were used during development of the flies. Maternal toxicity due to increasing the concentration of CH was observed as a large number of adult flies died. When the F1 progeny of the control and application groups were compared, CH was found to extend the process of metamorphosis and to decrease the total number of offspring. The embryotoxic effects on the offspring and an increase in the number of malformed offspring was identified as depending on feeding. It was found that the difference between the groups was significantly important (p < 0.05).


Drosophila melanogaster Chloral hydrate Developmental stages Maternal toxicity Embryotoxic effect 


Conflict of interest

The Authors declare that there is no conflict of interest.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Sabuncuoğlu Şerefeddin Health Services Vocational SchoolAmasya UniversityAmasyaTurkey
  2. 2.Department of Biology, Faculty of Art and ScienceErzincan UniversityErzincanTurkey
  3. 3.Department of Biology, Faculty of ScienceAtatürk UniversityErzurumTurkey

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