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Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2)

Abstract

The major polyphenols in green tea, (−)-epigallocatechin and (−)-epigallocatechin gallate, have been shown to enhance the phagocytic activity of macrophage-like cells; however, the mechanism involved was not clarified. In this study, we have identified that the catechins induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2.

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Acknowledgments

This work was supported by a grant for project research (Development of fundamental technology for analysis and evaluation of functional agricultural products and functional foods), Ministry of Agriculture, Fishery and Forestry, Japan.

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Correspondence to Manami Monobe.

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Monobe, M., Ema, K., Tokuda, Y. et al. Green tea catechin induced phagocytosis can be blocked by catalase and an inhibitor of transient receptor potential melastatin 2 (TRPM2). Cytotechnology 66, 561–566 (2014). https://doi.org/10.1007/s10616-013-9618-7

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Keywords

  • (−)-Epigallocatechin (EGC)
  • (−)-Epigallocatechin gallate (EGCG)
  • Phagocytosis
  • TRPM2
  • Hydrogen peroxide