, Volume 63, Issue 2, pp 153–161 | Cite as

Lactobacillus gasseri OLL2809 is effective especially on the menstrual pain and dysmenorrhea in endometriosis patients: randomized, double-blind, placebo-controlled study

  • Hiroyuki Itoh
  • Masayuki Uchida
  • Toshihiro SashiharaEmail author
  • Zai-Si Ji
  • Ji Li
  • Qianjue Tang
  • Shuang Ni
  • Linyi Song
  • Shuichi Kaminogawa
JAACT Special Issue


In this study, we evaluated the efficacy of Lactobacillus gasseri OLL2809 on endometriosis by the randomized, double-blind and placebo-controlled clinical study, especially against pain, which is one of the causative factors to decrease the quality of life. Sixty-six patients clinically diagnosed with endometriosis were enrolled in this study, 62 of which have successfully completed the trial. The tablets containing 100 mg of L. gasseri OLL2809 (active tablet, n = 29) or placebo tablets (n = 33) were ingested once a day for 12 weeks. Visual analog scale (VAS) of pain intensity at the menstrual period and verbal rating scale (VRS) of dysmenorrhea were significantly improved by the ingestion of the active tablets as compared with placebo tablets. There was no significant change of blood examination and biochemical examination of blood in the enrolled patients. Above results show that the tablet containing L. gasseri OLL2809 is effective on endometriosis, especially against menstrual pain and dysmenorrhea. Moreover, it was found that the tablet has no adverse effects. Therefore, it was suggested that the tablet containing L. gaserri OLL2809 contributes to improve the quality of life in the patients with endometriosis.


Lactobacillus gasseri OLL2809 Endometriosis Menstrual pain Dysmenorrhea 



Visual analog scale


Verbal rating scale


Natural killer




Quality of life


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Hiroyuki Itoh
    • 1
  • Masayuki Uchida
    • 1
  • Toshihiro Sashihara
    • 1
    Email author
  • Zai-Si Ji
    • 1
  • Ji Li
    • 2
  • Qianjue Tang
    • 2
  • Shuang Ni
    • 2
  • Linyi Song
    • 2
  • Shuichi Kaminogawa
    • 3
  1. 1.Food Science InstituteMeiji Dairies CorporationOdawara, KanagawaJapan
  2. 2.Department of Gynecology, Longhua HospitalShanghai University of Traditional Chinese MedicineShanghaiPeople’s Republic of China
  3. 3.Department of Food Science and Technology, College of Bioresource SciencesNihon UniversityFujisawa, KanagawaJapan

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