Abstract
Helichrysum Mill. (Asteraceae) species have been used in folk medicine for thousands of years in the world. The in vitro cytogenetic effects in human lymphocytes of nine Helichrysum taxa used in Turkey folk medicine were investigated. Blood samples were obtained from healthy donors, non-smoking volunteers, which were incubated and exposed to increasing concentrations of methanol extracts of Helichrysum taxa (0.01, 0.05, 0.1, 0.5 and 1 mg/mL). The inhibitory effects of H. stoechas (L.) Moench subsp. barrelieri (Ten.) Nyman, H. armenium DC. subsp. armenium, H. armenium DC. subsp. araxinum (Kirp.) Takht., H. plicatum DC. subsp. plicatum, H. compactum Boiss. and H. artvinense P.H.Davis & Kupicha on the mitotic index and replication index indicate that these taxa can have genotoxic and mutagenic effects. They should therefore not be used freely in alternative medicine although their antiproliferative activity may suggest anticarcinogenic properties. Increase effects of H. stoechas subsp. barrelieri, H. armenium subsp. armenium, H. armenium subsp. araxinum, H. chasmolycicum P.H.Davis, H. plicatum subsp. plicatum, H. compactum and H. artvinense on the micronucleus rates showed that these taxa can have genotoxic and carcinogenic effects.
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Acknowledgments
This study was supported with research projects (FBD-07-281 and FBT-06-82) by the Scientific Research Projects Fund of Erciyes University. The authors wish to thank Emine Olmez (Bozok University, Faculty of Science and Arts, Department of Biology) for sending blood samples used in this study.
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Eroğlu, H.E., Aksoy, A., Hamzaoğlu, E. et al. Cytogenetic effects of nine Helichrysum taxa in human lymphocytes culture. Cytotechnology 59, 65–72 (2009). https://doi.org/10.1007/s10616-009-9193-0
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DOI: https://doi.org/10.1007/s10616-009-9193-0