, Volume 56, Issue 3, pp 209–217 | Cite as

Potential neural progenitor cells in fetal liver and regenerating liver

  • Fuminari KomatsuEmail author
  • Imre Farkas
  • Hiroyasu Akatsu
  • Kiyohide Kojima
  • Takeo Fukushima
  • Hidechika Okada
Original Research


From unfractionated embryonic mice liver cells, appreciable amount of spherical bodies containing nestin-positive cells were generated in the presence of neuronal growth factors. Following cultivation on poly-d-lysine/laminin-coated slips, approximately 70% of the cells expressed neuronal markers, and 16% had long processes. Functional analysis of these long-process-bearing cells with the whole-cell patch clamp method showed an inward current in response to glutamate, GABA, and serotonin as the neuronal characteristics. Furthermore, regenerating liver in adult mice also contained nestin-positive cells to the same extent as fetal liver. Regenerating liver could have potential as a source of neural cells for autologous transplantation.


Liver Nestin Neural progenitor cell 


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Fuminari Komatsu
    • 1
    • 2
    • 3
    Email author
  • Imre Farkas
    • 3
    • 4
  • Hiroyasu Akatsu
    • 1
  • Kiyohide Kojima
    • 1
  • Takeo Fukushima
    • 2
  • Hidechika Okada
    • 1
    • 3
  1. 1.Choju Medical InstituteFukushimura HospitalNoyori-cho, ToyohashiJapan
  2. 2.Department of Neurosurgery, Faculty of MedicineFukuoka UniversityFukuokaJapan
  3. 3.Department of BiodefenseNagoya City University Graduate School of Medical SciencesMizuho-cho, NagoyaJapan
  4. 4.Hungarian Academy of Medical ScienceBudapestHungary

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