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Neurobehavioral Therapies in the 21st Century: Summary of an Emerging Field and an Extended Example of Cognitive Control Training for Depression

Abstract

The promise of a new generation of therapies targeted to address neurobiological mechanisms thought to underlie psychological disorders, particularly depression, using cognitive and behavioral techniques is discussed. Relationships between such neurobehaviorally focused therapies and other psychological and rehabilitative interventions are also discussed. Their potential utility as adjuncts to conventional treatment, and the importance of multi-method assessment in their evaluation are emphasized. Finally, initial data from a neurobehavioral “cognitive control training” (CCT) adjunctive intervention for severe unipolar depression is presented as an extended example. These data suggest that CCT aids in reducing both physiological mechanisms underlying depression as well as depressive symptomatology.

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Acknowledgements

We gratefully acknowledge contributions of the volunteers who participated in this study as well as Lisa Farace, Agnes Haggerty, Emilie Muelly, and Dimple Sodhi for contributions to data collection, to Agnes Haggerty and Aaron Beck for comments on previous drafts, Kate Fissell and John Scott, for assistance in analyses, and Tiffany Painter and the staff of the WPIC Intensive Outpatient Program for consistent support for the reported trial. This research was supported by MH64159, NARSAD, MH58356, and MH30915. The idea for this article was born at a NIDA sponsored meeting in September, 2004 entitled Cognitive and Affective Neuroscience and Behavioral Treatment Development: New Directions for Translational Research, and reflects discussion which occurred at that meeting.

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Siegle, G.J., Ghinassi, F. & Thase, M.E. Neurobehavioral Therapies in the 21st Century: Summary of an Emerging Field and an Extended Example of Cognitive Control Training for Depression. Cogn Ther Res 31, 235–262 (2007). https://doi.org/10.1007/s10608-006-9118-6

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Key words

  • Depression
  • Therapy
  • Neuroscience
  • fMRI