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Two New Stilbenes from the Whole Plant of Arundina graminifolia and Their Anti-SARS-CoV-2 Activity

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Chemistry of Natural Compounds Aims and scope

Two new stilbenes, 5-methoxy-6-(4-methoxystyryl)-3-methylbenzofuran (1) and 5-methoxy-6-(4- hydroxystyryl)-3-methylbenzofuran (2), together with six known ones, bauhiniastatin D (3), gramideoxybenzoin B (4), gramistilbenoid A (5), gramistilbenoid B (6), gramniphenol H (7), and pterostilbene (8), were isolated from the whole plants of Arundina graminifolia. Their structures were established by their 1D, 2D NMR, and MS spectral data. Compounds 1 and 2 were tested for their anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) activity. The results revealed that compound 1 exhibited potential activity with IC50 of 17.4 μM for delta strain and 28.5 μM for Omicron BA.1 strain, compound 2 also showed potential activity with IC50 of 15.3 μM for delta strain and 22.6 μM for Omicron BA.1 strain, respectively.

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Acknowledgment

This project was supported financially by the National Natural Science Foundation of China (No. 32260111), the innovative Research Team of Dehong Prefecture (2022RC009), the youth Academic and Technical Leaders Project of Yunnan Province (202005AC160061), and the Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicinal Resources, State Ethnic Affairs Commission, Yunnan Minzu University, 650031, Kunming, P. R. China

    Gui-Feng Li, Yan-Qun Zhang, Gui-Juan Zhao, Gui Pu, Yue-Yu Ma, Min Zhou, Yin-Ke Li, Dong Miao, Qiu-fen Hu & Xin-Zhou Yang

  2. Institute of Science and Technology, Dehong Teachers College, Dehong, 678400, China

    Xin-Zhou Yang

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  1. Gui-Feng Li
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  2. Yan-Qun Zhang
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  5. Yue-Yu Ma
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  6. Min Zhou
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  9. Qiu-fen Hu
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Correspondence to Qiu-fen Hu or Xin-Zhou Yang.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2024, pp. 351–354.

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Li, GF., Zhang, YQ., Zhao, GJ. et al. Two New Stilbenes from the Whole Plant of Arundina graminifolia and Their Anti-SARS-CoV-2 Activity. Chem Nat Compd 60, 393–397 (2024). https://doi.org/10.1007/s10600-024-04335-1

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  • DOI: https://doi.org/10.1007/s10600-024-04335-1

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