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Two New Benzofulvene Sesquiterpenoids from the Stems of Nicotiana tabacum and their Antibacterial Activity

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Two new benzofulvene sesquiterpenoids, tabanoids A and B (1 and 2) as well as five known sesquiterpenoids (3–7) were isolated from the stem of Nicotiana tabacum. Their structures were determined mainly by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1 and 2 were tested for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity. The results revealed that compounds 1 and 2 showed good inhibition with IZD of 15.2 ± 2.5, and 12.8 ± 2.2 mm, respectively.

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Acknowledgment

This project was supported financially by the Foundation Yunnan Tobacco Industry Co. Ltd. (No. JB2022XY03), the Foundation of Yunnan Tobacco Company (No. 2021530000241009), and the Foundation of Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Yunnan Key Laboratory of Tobacco Chemistry, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Shan-Zhai Shang, Jia-Meng Dai, Wen Xiong, Wei Zhao, Yong Li, Hao-Cheng Cai, Wei-Guang Wang, Qiu-Fen Hu & Jie-Yun Cai

  2. Yunnan Tobacco Quality Supervision and Test Station, Kunming, 650106, Yunnan, P. R. China

    Shan-Zhai Shang, Hui-Ping Wang, Shi-Chun Qin & Jie-Yun Cai

  3. Key Laboratory of Chemistry in Ethnic Medicinal Resources, Yunnan Minzu University, 650031, Kunming, P. R. China

    Wei-Guang Wang & Qiu-Fen Hu

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  1. Shan-Zhai Shang
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  2. Jia-Meng Dai
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Correspondence to Jie-Yun Cai.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2023, pp. 922–925.

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Shang, SZ., Dai, JM., Xiong, W. et al. Two New Benzofulvene Sesquiterpenoids from the Stems of Nicotiana tabacum and their Antibacterial Activity. Chem Nat Compd 59, 1092–1096 (2023). https://doi.org/10.1007/s10600-023-04203-4

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  • DOI: https://doi.org/10.1007/s10600-023-04203-4

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