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Two New Antibacterial Naphthoquinones from a Cigar Tobacco-Derived Endophytic Fusarium solani

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Chemistry of Natural Compounds Aims and scope

In this study, two new (1 and 2), together with five known (3–7) naphthoquinones were isolated from the cigar tobacco-derived endophytic Fusarium solani. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. The new compounds were evaluated for antibacterial activities against Pseudomonas syringae (the main pathogenic sources of tobacco angular leaf spot disease). Interestingly, compounds 1 and 2 exhibited inhibitory effects with MIC50 values of 6.8 and 5.9 μg/mL, respectively. These rates are lower than that of the positive control (agricultural streptomycin, with MIC50 of 2.2 μg/mL).

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Acknowledgment

This project was supported by the Foundation of the China Tobacco Monopoly Bureau Grants and Yunnan Provincial Tobacco Monopoly Bureau Grants (110202103018, 2022530000241004), the National Natural Science Foundation of China (No. 32260111), and the Foundation of Yunnan Innovative Research Team (2019HC020).

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Authors and Affiliations

  1. Key Laboratory of Natural Products Synthetic Biology of Ethnic Medicina Endophytes, Yunnan Minzu University, 650500, Kunming, P. R. China

    Wan-Ya Qiu, Meng-Si Chen, Wei Li, Wei-Guang Wang, Yin-Ke Li & Qiu-Fen Hu

  2. Tobacco Research Institute, Chinese Academy of Agricultural Sciences, 266101, Qingdao, P. R. China

    Wan-Ya Qiu, Meng-Si Chen & Da-Ping Gong

  3. Yunnan Academy of Tobacco Agricultural Sciences, 650021, Kunming, P. R. China

    Yu-Ping Wu, Guang-Hui Kong, Qiu-Fen Hu & Gao-Kun Zhao

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  1. Wan-Ya Qiu
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  2. Meng-Si Chen
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  3. Yu-Ping Wu
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  4. Wei Li
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  6. Guang-Hui Kong
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  7. Wei-Guang Wang
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  8. Yin-Ke Li
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  9. Qiu-Fen Hu
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Corresponding authors

Correspondence to Qiu-Fen Hu or Gao-Kun Zhao.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2023, pp. 889–892.

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Qiu, WY., Chen, MS., Wu, YP. et al. Two New Antibacterial Naphthoquinones from a Cigar Tobacco-Derived Endophytic Fusarium solani. Chem Nat Compd 59, 1051–1055 (2023). https://doi.org/10.1007/s10600-023-04194-2

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  • DOI: https://doi.org/10.1007/s10600-023-04194-2

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