Bromination of the purine alkaloid triacanthine by N-bromosuccinimide in CHCl3, AcOH, and various alcohols was studied. The new derivatives 8-bromo-, 12,13-dibromo-, 8,12-dibromo-13-hydroxymethyl-, hydroxyethyl-, hydroxypropyl-, and hydroxybutyltriacanthine were prepared. The structures of the prepared compounds were proven using 1H and 13C NMR spectral data and X-ray crystal structure analyses.
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Translated from Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2023, pp. 747–751.
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Rakhimov, S.B., Vinogradova, V.I., Turgunov, K.K. et al. Bromination of Triacanthine. Chem Nat Compd 59, 886–890 (2023). https://doi.org/10.1007/s10600-023-04141-1
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DOI: https://doi.org/10.1007/s10600-023-04141-1