A new coumarin, methyl (E)-4-((6-methoxy-2-oxo-2H-chromen-7-yl)oxy)-2-methylbut-2-enoate (1), has been isolated from the rhizomes of Polygonatum chingshuishanianum, together with six known compounds – scopoletin (2), rutin (3), isoquercetin (4), hyperoside (5), (3R)-5,7-dihydroxy-3-(2′,4′-dihydroxybenzyl)-chroman-4-one (6), and (3R)-5,7-dihydroxy-6-methoxy-8-methyl-3-(2′,4′-dihydroxybenzyl)-chroman-4-one (7). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates compounds 3–6 showed potent inhibition with IC50 values of 10.25 ± 0.75, 17.60 ± 1.28, 18.82 ± 1.63, and 24.93 ± 2.07 μM, respectively, against LPS-induced NO generation.
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Acknowledgment
This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 109-2320-B-010-029-MY3), awarded to Prof. J.-J. Chen. This work was also supported by a grant from Yuan′s General Hospital (YGH 22-009).
Chieh-Yang Cheng and Chien-Ming Huang have contributed equally to this manuscript.
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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2023, pp. 705–707
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Cheng, CY., Huang, CM., Lin, CL. et al. A New Coumarin and Anti-Inflammatory Constituents from Polygonatum chingshuishanianum. Chem Nat Compd 59, 835–838 (2023). https://doi.org/10.1007/s10600-023-04129-x
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DOI: https://doi.org/10.1007/s10600-023-04129-x