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A New Cinnamic Acid Derivative and Anti-Inflammatory Constituents from Capparis lanceolaris

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Chemistry of Natural Compounds Aims and scope

A new cinnamic acid derivative, (E)-3-(4-(((E)-4-hydroxy-3-methylbut-2-en-1-yl)oxy)phenyl)acrylic acid (1), has been isolated from the roots of Capparis lanceolaris, together with six known compounds, luteolin (2), kaempferol (3), apigenin (4), catechin (5), trans-ferulic acid (6), and vanillin (7). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, luteolin (2), kaempferol (3), apigenin (4), and catechin (5) showed potent inhibition with IC50 values of 26.24 ± 1.78, 20.38 ± 1.36, 22.8 ± 1.57, and 42.5 ± 2.24 μM respectively, against LPS-induced NO generation.

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Acknowledgment

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 109-2320-B-010-029-MY3), awarded to Prof. J.-J. Chen. This work was also supported by grants from the Far Eastern Memorial Hospital–National Yang Ming Chiao Tung University Joint Research Program (111DN18) and Pingtung Christian Hospital (PS 111027). Fu-Sen Wu and Chien-Ming Huang have contributed equally to this manuscript.

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Authors and Affiliations

  1. Department of Pharmacy, Far Eastern Memorial Hospital, 220, New Taipei City, Taiwan

    Fu-Sen Wu

  2. Division of Pharmacy, Cheng Hsin General Hospital, 112, Taipei, Taiwan

    Chien-Ming Huang

  3. Department of Pharmacy, Tajen University, 907, Pingtung, Taiwan

    Li-Chai Chen

  4. Institute of Microbiology and Immunology, National Defense Medical Center, 114, Taipei, Taiwan

    Tsung-Hsien Chang

  5. Institute of BioPharmaceutical Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan

    Chih-Wen Shu

  6. National Museum of Marine Biology and Aquarium, 944, Pingtung, Taiwan

    Ping-Jyun Sung

  7. Institute of Traditional Medicine, School of Medicine, National Yang Ming Chiao Tung University, 112, Taipei, Taiwan

    Yi-Cheng Chu

  8. Department of Life Science, Fu Jen Catholic University, 242, New Taipei City, Taiwan

    Ming-Jen Cheng

  9. Department of Pharmacy, Pingtung Christian Hospital, 900, Pingtung, Taiwan

    Jen-Wen Hsiao

  10. Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, 112, Taipei, Taiwan

    Jih-Jung Chen

  11. Department of Medical Research, China Medical University Hospital, China Medical University, 404, Taichung, Taiwan

    Jih-Jung Chen

Authors
  1. Fu-Sen Wu
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  2. Chien-Ming Huang
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  3. Li-Chai Chen
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  4. Tsung-Hsien Chang
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  5. Chih-Wen Shu
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  6. Ping-Jyun Sung
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  7. Yi-Cheng Chu
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  8. Ming-Jen Cheng
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  9. Jen-Wen Hsiao
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  10. Jih-Jung Chen
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Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2023, pp. 418–420.

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Wu, FS., Huang, CM., Chen, LC. et al. A New Cinnamic Acid Derivative and Anti-Inflammatory Constituents from Capparis lanceolaris. Chem Nat Compd 59, 493–496 (2023). https://doi.org/10.1007/s10600-023-04033-4

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  • DOI: https://doi.org/10.1007/s10600-023-04033-4

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