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Lignans With α-Glucosidase Inhibitory Activity from Codonopsis pilosula

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Chemistry of Natural Compounds Aims and scope

The chemical constituents of Codonopsis pilosula (Franch.) Nannf. were isolated and purified by column chromatography. Two lignans were obtained from an ethanol extract of the roots of C. pilosula, including one new lignan [diethyl lithospermate (1)] and one new natural product [diethyl lithospermate B (2)]. The structures of these compounds were identified using spectroscopic data. The α-glucosidase inhibitory effects of all compounds were measured by the p-nitrophenyl-α-D-glucopyranoside method. Compounds 1 and 2 exhibited good inhibitory activity with half-maximal inhibitor concentrations of 0.79 ± 0.03 μM and 0.16 ± 0.02 μM, respectively.

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This work was financially supported by the National Key Research and Development Program of China (Grant Nos. 2018YFC1706300 and 2018YFC1706304), the Natural Science Foundation of Gansu Province (Grant Nos. 21JR7RA444 and 21JR7RA477), the Major Projects in Gansu Province (Grant No. 21ZD4FA013), and the Science and Technology Project of Lanzhou City (Grant No. 2018-4-61). We thank Gabrielle David, PhD, from Liwen Bianji (Edanz) ( for editing the English text of a draft of this manuscript.

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Correspondence to Fang-Di Hu or Dong-Qing Fei.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2023, pp. 367–370.

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Wang, RY., Zhan, XQ., Wang, MJ. et al. Lignans With α-Glucosidase Inhibitory Activity from Codonopsis pilosula. Chem Nat Compd 59, 431–435 (2023).

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