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A New Chloro-Containing γ-Butyrolactone from the Mangrove Endophytic Fungus Neofusicoccum parvum Y2NBKZG1016

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Chemistry of Natural Compounds Aims and scope

A new chloro-containing γ-butyrolactone derivative 1, together with eight known metabolites (2–9), were isolated from the mangrove endophytic fungus Neofusicoccum parvum Y2NBKZG1016. Its structure was identified as (4S,5S,6S,7R)-4-(3-chloro-1,2-dihydroxybutyl)-butyrolactone (1) by spectral data and chemical method. The otoprotective effects of all compounds and the ability of 1 to inhibit the release of lipopolysaccharide (LPS)-induced nitric oxide (NO) from RAW264.7 were determined.

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Acknowledgment

This research was financially supported by the National Natural Science Foundation of China (Grant No. 82074028), the Natural Science Foundation of Guangdong Province (Grant No. 2021A1515012230), and Guangzhou Basic and Applied Basic Research Foundation (Grant No. 202201010721).

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Authors and Affiliations

  1. School of Pharmacy, Guangdong Pharmaceutical University, 510006, Guangzhou, P. R. China

    Xiaoting Xie, Suping Xiao, Huiyi Liao, Qingjian Jiang & Lu Wen

  2. Guangdong Provincial Key Laboratory of Advanced Drug Delivery & Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System & Class III Laboratory of Modern Chinese Medicine Preparation & Key Laboratory of Modern Chinese Medicine of Education Department of Guangdong Province, Center for Drug Research and Development, Guangdong Pharmaceutical University, 510006, Guangzhou, P. R. China

    Gang Chen

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  1. Xiaoting Xie
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  2. Suping Xiao
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  3. Huiyi Liao
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  4. Qingjian Jiang
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  5. Gang Chen
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  6. Lu Wen
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Corresponding authors

Correspondence to Gang Chen or Lu Wen.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2023, pp. 361–363.

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Xie, X., Xiao, S., Liao, H. et al. A New Chloro-Containing γ-Butyrolactone from the Mangrove Endophytic Fungus Neofusicoccum parvum Y2NBKZG1016. Chem Nat Compd 59, 424–427 (2023). https://doi.org/10.1007/s10600-023-04015-6

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  • DOI: https://doi.org/10.1007/s10600-023-04015-6

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