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Aminomethylation of Uracil and 6-Methyluracil by 3,4-dimethoxyphenylethylamine and Tetrahydroisoquinoline Derivatives

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Chemistry of Natural Compounds Aims and scope

The Mannich reactions of uracil and 6-methyluracil with homoveratrylamine and 1-aryltetrahydroisoquinolines in EtOH and dioxane were studied. 5-[(2-Hydroxymethyl)-4,5-dimethoxyphenylethylamino)methyl]-6-methylpyrimidine-2,4(1H, 3H)-dione was formed in EtOH in addition to the usual products (in dioxane).

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Acknowledgment

The work was financially supported by the Ministry of Innovative Development, Cabinet of Ministers, Republic of Uzbekistan (Grant MRU-FA-21/2017).

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Authors and Affiliations

  1. S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170, Tashkent, Uzbekistan

    Sh.N. Zhurakulov, Sh.B. Rakhimov, M. A. Kodirov, V. I. Vinogradova & Sh.Sh. Sagdullaev

  2. National University of Uzbekistan named after Mirzo Ulugbek, 100174, Tashkent, Uzbekistan

    Sh.N. Zhurakulov

Authors
  1. Sh.N. Zhurakulov
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  2. Sh.B. Rakhimov
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  3. M. A. Kodirov
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  4. V. I. Vinogradova
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  5. Sh.Sh. Sagdullaev
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Correspondence to Sh.N. Zhurakulov.

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Translated from Khimiya Prirodnykh Soedinenii, No. 2, March–April, 2023, pp. 280–283.

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Zhurakulov, S., Rakhimov, S., Kodirov, M.A. et al. Aminomethylation of Uracil and 6-Methyluracil by 3,4-dimethoxyphenylethylamine and Tetrahydroisoquinoline Derivatives. Chem Nat Compd 59, 331–335 (2023). https://doi.org/10.1007/s10600-023-03987-9

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  • DOI: https://doi.org/10.1007/s10600-023-03987-9

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