The composition of water-soluble polysaccharides (fucoidans and laminarans) from the two Vietnamese brown algae Sargassum microcystum and S. serratum was investigated. It was found that S. microcystum produced fucoidan and laminaran with predominance of the latter; S. serratum, only fucoidan. The fucoidans were sulfated galactofucans and a sulfated and acetylated heteropolysaccharide of complicated structure. The laminaran had a main chain of 1,3-bound β-D-glucose residues with single branches on C6 (ratio of 1,3:1,6 bonds = 4:1). The sulfates occupied the 2-, 4-, and 6-positions in the obtained sulfated laminaran derivative. A study of the biological activities of all obtained polysaccharides showed a lack of cytotoxicity and low activity against RPMI-7951 human melanoma cells with significantly more pronounced and selective activity against HuTu-80 human duodenum adenocarcinoma cells.
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Acknowledgment
The work was financially supported by the Russian Foundation for Basic Research and the Vietnam Academy of Science and Technology under scientific project No. 21-53-54003. VVS and RAS contributed equally to the work.
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Translated from Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2023, pp. 5–8.
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Surits, V.V., Shkrabov, R.A., Usoltseva, R.V. et al. Structural Characteristics and Anticancer Activity of Water-Soluble Polysaccharides from Vietnamese Brown Algae Sargassum microcystum and S. serratum. Chem Nat Compd 59, 1–5 (2023). https://doi.org/10.1007/s10600-023-03905-z
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DOI: https://doi.org/10.1007/s10600-023-03905-z