Previously unknown C-19 lappaconitine derivatives were prepared via [3 + 2] cycloaddition reactions of a nitrone based on lappaconitine with compounds containing a triple bond, i.e., propargyl alcohol, methyl propiolate, phenylacetylene, 3-phenoxypropyne-1, and propargyl aldehyde diethylacetal.
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The work was performed on topic No. 122031400260-7, “Synthesis of biologically active compounds based on natural compounds. Creation of ecologically safe materials and technologies.”
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Translated from Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2022, pp. 934–938.
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Tsyrlina, E.M., Gabbasov, T.M., Lobov, A.N. et al. New C-19 Lappaconitine Derivatives. Chem Nat Compd 58, 1108–1113 (2022). https://doi.org/10.1007/s10600-022-03878-5
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DOI: https://doi.org/10.1007/s10600-022-03878-5