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A New Drimane Sesquiterpene Ester from the Marine-Derived Fungus Penicillium chrysogenum LD-201810

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Chemistry of Natural Compounds Aims and scope

Chrysoride A (1), a new natural product belonging to the family of drimane sesquiterpene esters, was isolated from a marine-derived fungus Penicillium chrysogenum LD-201810. Its structure was established by detailed interpretation of 1D (1H and 13C) NMR, 2D (1H–1H COSY, HSQC, HMBC, and NOESY) NMR, and HR-ESI-MS data. Chrysoride A (1) exhibited moderate cytotoxicity against HepG2 and HeLa cancer cell lines with IC50 values of 28.9 and 35.6 μM, respectively.

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References

  1. P. Zhang, Q. Wei, X. L. Yuan, and K. Xu, Bioorg. Chem., 99, 103840 (2020).

    Article  CAS  PubMed  Google Scholar 

  2. L. L. Jiang, J. X. Tang, Y. H. Bo, Y. Z. Li, T. Feng, H. W. Zhu, X. Yu, X. X. Zhang, J. L. Zhang, and W. Wang, Mar. Drugs, 18, 276 (2020).

    Article  CAS  PubMed Central  Google Scholar 

  3. Y. Ge, W. L. Tang, Q. R. Huang, M. L. Wei, Y. Z. Li, L. L. Jiang, C. L. Li, X. Yu, H. W. Zhu, G. Z. Chen, J. L. Zhang, and X. X. Zhang, Front. Microbiol., 12, 727670 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  4. M. A. Hayes, S. K. Wrigley, I. Chetland, E. E. Reynolds, A. M. Ainsworth, D. V. Renno, M. A. Latif, X. M. Cheng, D. J. Hupe, P. Charlton, and A. M. Doherty, J. Antibiot., 49, 505 (1996).

    Article  CAS  Google Scholar 

  5. G. F. Neuhaus and S. Loesgen, J. Nat. Prod., 84, 37 (2021).

    Article  CAS  PubMed  Google Scholar 

  6. D. L. Guo, L. Qiu, D. Feng, X. He, X. H. Li, Z. X. Cao, Y. C. Gu, L. Mei, F. Deng, and Y. Deng, Nat. Prod. Res., 34, 958 (2020).

    Article  CAS  PubMed  Google Scholar 

  7. X. L. Yuan, X. Q. Li, K. Xu, X. D. Hou, Z. F. Zhang, L. Xue, X. M. Liu, and P. Zhang, Front. Pharmacol., 11, 570450 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgment

This work was funded by the National Key Research and Development Program of China (Grant Nos. 2017YFD0500806 and 2018YFD0501402), the Major Agricultural Applied Technological Innovation Projects of Shandong Province (to Xingxiao Zhang), the Key Research and Development Plan of Yantai (Nos. 2020XDRH101, 2021YT06000060, 2021YT06000636, and 2018XSCC045), the Natural Science Foundation of Shandong Province (Nos. ZR201911120018 and ZR2014HL061), and the Innovation Team Project for Modern Agricultural Industrious Technology System of Shandong Province (SDAIT-11-10).

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Authors and Affiliations

  1. School of Life Sciences, Ludong University, 264025, Yantai, P. R. China

    Qingrong Huang, Yanhua Wang, Xiaoyan Chi, Chong Liu & Jianlong Zhang

  2. Shandong Provincial Key Laboratory of Quality Safty Monitoring and Risk Assessment for Animal Products, 250022, Ji’nan, P. R. China

    Qingrong Huang, Yanhua Wang, Xiaoyan Chi, Chong Liu & Jianlong Zhang

  3. Yantai Key Laboratory of Animal Pathogenetic Microbiology and Immunology, 264025, Yantai, P. R. China

    Qingrong Huang & Jianlong Zhang

  4. Shandong Aquaculture Environmental Control Engineering Laboratory, 264000, Yantai, Shandong, P. R. China

    Yanhua Wang & Chong Liu

Authors
  1. Qingrong Huang
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  2. Yanhua Wang
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  3. Xiaoyan Chi
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  4. Chong Liu
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Correspondence to Jianlong Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 6, November–December, 2022, pp. 875–877.

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Huang, Q., Wang, Y., Chi, X. et al. A New Drimane Sesquiterpene Ester from the Marine-Derived Fungus Penicillium chrysogenum LD-201810. Chem Nat Compd 58, 1042–1044 (2022). https://doi.org/10.1007/s10600-022-03864-x

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  • DOI: https://doi.org/10.1007/s10600-022-03864-x

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