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Study on Bioactive Secondary Metabolites from the Mangrove-Derived Fungus Penicillium verruculosum TGM14

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Chemistry of Natural Compounds Aims and scope

A new compound, named penicillquei C (1), and eight known compounds (2–9), were isolated from the fermentation broth of mangrove-derived fungus Penicillium verruculosum TGM14. The structure of compound 1 was identified by comprehensive analyses of 1D and 2D NMR and HR-ESI-MS spectroscopic data, and calculated electronic circular dichroism (ECD) spectra. Compound 2 was isolated from the genus Penicillium for the first time. Compound 4 exhibited potent antioxidant activity with an IC50 value of 4.7 μM, which is stronger than positive control trolox (IC50 = 13.0 μM). Compound 4 also showed wide antibacterial activities against Staphylococcus aureus, Bacillus cereus, and Escherichia coli, with the same MIC value of 25.0 μg/mL.

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ACKNOWLEDGMENT

This work was supported by the National Natural Science Foundation of China (Nos. 31760093 and 32160108), Hainan Provincial Natural Science Foundation of China (No. 220RC593), Key Research and Development Program of Hainan Province (No. ZDYF2019183).

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Authors and Affiliations

  1. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, Hainan, P. R. China

    Bin Wang, Xu-Hua Nong, Wei-Nv Zeng, Shan-Shan Li, Gao-Yu Li, Jing Liu, Guo-Lei Huang & Cai-Juan Zheng

  2. Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou, 571158, Hainan, P. R. China

    Bin Wang, Xu-Hua Nong, Wei-Nv Zeng, Shan-Shan Li, Gao-Yu Li, Jing Liu, Guo-Lei Huang & Cai-Juan Zheng

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  1. Bin Wang
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  2. Xu-Hua Nong
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  3. Wei-Nv Zeng
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  4. Shan-Shan Li
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  5. Gao-Yu Li
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  7. Guo-Lei Huang
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  8. Cai-Juan Zheng
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Correspondence to Guo-Lei Huang or Cai-Juan Zheng.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2022, pp. 687–689.

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Wang, B., Nong, XH., Zeng, WN. et al. Study on Bioactive Secondary Metabolites from the Mangrove-Derived Fungus Penicillium verruculosum TGM14. Chem Nat Compd 58, 812–815 (2022). https://doi.org/10.1007/s10600-022-03804-9

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  • DOI: https://doi.org/10.1007/s10600-022-03804-9

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