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A New Geranylated Lignan from Oenanthe javanica and Anti-Inflammatory Activity

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Chemistry of Natural Compounds Aims and scope

A new geranylated lignan, named 8′-geranylated lignan A (1), and a known lignan (2) were isolated from Oenanthe javanica (Blume) DC., to our knowledge, for the first time. Compounds 1 and 2 were determined by analyzing their extensive spectral data and comparing them with related references. Compounds 1 and 2 exhibited anti-inflammatory activities with IC50 values of 15.24 ± 0.39 μM and 20.07 ± 0.54 μM, which displayed stronger NO inhibitory activities than the positive control (L-NMMA, IC50 = 44.52 ± 0.71 μM).

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Acknowledgment

This study was supported by Jiangxi Provincial Natural Science Foundation (20202BAB216036).

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Authors and Affiliations

  1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, P. R. China

    Rongrui Wei & Qinge Ma

  2. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, 473061, Nanyang, Henan, P. R. China

    Zhipei Sang

  3. School of Pharmaceutical Sciences, Hainan University, 570228, Haikou, Hainan, P. R. China

    Zhipei Sang

Authors
  1. Rongrui Wei
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  2. Zhipei Sang
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  3. Qinge Ma
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Corresponding authors

Correspondence to Zhipei Sang or Qinge Ma.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2022, pp. 684–686.

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Wei, R., Sang, Z. & Ma, Q. A New Geranylated Lignan from Oenanthe javanica and Anti-Inflammatory Activity. Chem Nat Compd 58, 808–811 (2022). https://doi.org/10.1007/s10600-022-03803-w

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