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α-Glucosidase Inhibitory Constituents from Trichosanthis Radix

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Chemistry of Natural Compounds Aims and scope

One new compound, β-D-apiofuranosyl-(1→6)-1-ethyl-O-β-D-glucopyranoside (1), and 11 known compounds were isolated from Trichosanthis Radix. Their structures were mainly elucidated by NMR and MS spectra. All the isolated compounds were tested for their inhibitory activities against α-glucosidase, and compound 11 exhibited potential inhibitory activity with an IC50 value of 36.41 ± 0.54 μM.

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Acknowledgment

This investigation was supported by grants from the Strategic Pilot Program A of the Chinese Academy of Sciences (Grant No. XDA12040219), the Institute of Drug Innovation of the Chinese Academy of Sciences (Grant No. CASIMM0520181002), and the Science and Technology Major Project of Yunnan Province under Grant (202102AA100014).

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Authors and Affiliations

  1. Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, 650223, Kunming, P. R. China

    Xue-Lin Chen, Kun Zhang, Ji-Yan Ni, Xia Zhao & Yu-Mei Zhang

  2. University of Chinese Academy of Sciences, 100049, Beijing, P. R. China

    Xue-Lin Chen, Ji-Yan Ni & Yu-Mei Zhang

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  1. Xue-Lin Chen
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  2. Kun Zhang
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  3. Ji-Yan Ni
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  4. Xia Zhao
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  5. Yu-Mei Zhang
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Correspondence to Yu-Mei Zhang.

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Published in Khimiya Prirodnykh Soedinenii, No. 5, September–October, 2022, pp. 674–676.

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Chen, XL., Zhang, K., Ni, JY. et al. α-Glucosidase Inhibitory Constituents from Trichosanthis Radix. Chem Nat Compd 58, 796–798 (2022). https://doi.org/10.1007/s10600-022-03800-z

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  • DOI: https://doi.org/10.1007/s10600-022-03800-z

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