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Synthesis and Cytotoxicity of Novel 4′-O-Demethylpodophyllotoxin Derivatives as Potential Anticancer Agents

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Chemistry of Natural Compounds Aims and scope

Ten 4β-N-substituted derivatives of 4′-O-demethylpodophyllotoxin were designed by aldehydes reacting with 4′-O-demethylpodophyllotoxin. Their cytotoxicity against cancer cell lines (HeLa) was evaluated using the MTT assay. Compounds 7a–7d, 7f, 7g, and 7h exhibited pronounced stronger activity than that of the positive control etoposide (VP-16). 4β-N-Substituted derivatives of 4′-O-demethylpodophyllotoxin were worthy of further study with potential antitumor activity.

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Acknowledgment

This work was supported by the National Natural Science Foundation of China (No. 30873363).

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Authors and Affiliations

  1. Tianjin First Central Hospital, 300192, Tianjin, P. R. China

    Dan-li Tian

  2. Logistics University of Chinese People’s Armed Police Forces, 300309, Tianjin, P. R. China

    Hong Chen & Gang Luo

  3. Tianjin Medical University General Hospital, 300052, Tianjin, P. R. China

    Chun-po Liang

Authors
  1. Dan-li Tian
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  2. Hong Chen
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  3. Gang Luo
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  4. Chun-po Liang
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Corresponding author

Correspondence to Chun-po Liang.

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Published in Khimiya Prirodnykh Soedinenii, No. 4, July–August, 2022, pp. 536–540. Original

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Tian, Dl., Chen, H., Luo, G. et al. Synthesis and Cytotoxicity of Novel 4′-O-Demethylpodophyllotoxin Derivatives as Potential Anticancer Agents. Chem Nat Compd 58, 628–633 (2022). https://doi.org/10.1007/s10600-022-03757-z

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  • DOI: https://doi.org/10.1007/s10600-022-03757-z

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