A new C19-diterpenoid alkaloid, named 17-acetylaconitine A (1), was isolated from salted Aconiti lateralis Radix Praeparata. The structure of compound 1 was elucidated by 1D and 2D NMR, HR-ESI-MS, IR, and related references. Compound 1 exhibited moderate neuroprotective activity with IC50 value of 4.51 μM, which was evaluated for its neuroprotective activity against 6-OHDA-induced cell death in SH-SY5Y cells with curcumin as positive control.
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This work was supported by the National Key Research & Development Project (2019YFC1604905).
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 439–441.
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Wei, R., Chen, L. & Ma, Q. A New C19-Diterpenoid Alkaloid from Salted Aconiti Lateralis Radix Praeparata. Chem Nat Compd 58, 516–519 (2022). https://doi.org/10.1007/s10600-022-03721-x
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DOI: https://doi.org/10.1007/s10600-022-03721-x