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Two New Nitrogenous Compounds from the Seeds of Brassica napus

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Chemistry of Natural Compounds Aims and scope

Two new nitrogenous compounds identified as (2S)-2-sinapoyl-4-pentenenitrile (1) and brassicalkaloid A (2) have been isolated from the seed of Brassica napus L. along with four known alkaloids (3–6). The chemical structures of the new compounds were determined by detailed analysis of spectral data including 1D and 2D NMR spectroscopy. The antineuroinflammatory activity of the isolated compounds was investigated. Brassicalkaloid A (2) and coixspirolactam C (5) were found to exhibit potent activities with IC50 values of 36.6 ± 0.04 μM and 51.0 ± 0.01 μM.

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Acknowledgment

This work was supported by Major Drugs Innovation and Development (2014ZX09304307001) and the Special Research of Traditional Chinese Medicine Industry (201307009).

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Authors and Affiliations

  1. National Institutes for Food and Drug Control, 100050, Beijing, P. R. China

    Wenguang Jing, Feng Wei & Shuangcheng Ma

  2. China Academy of Chinese Medical Sciences, 100700, Beijing, P. R. China

    Xiaoliang Zhao & An Liu

Authors
  1. Wenguang Jing
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  2. Xiaoliang Zhao
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  3. An Liu
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  4. Feng Wei
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  5. Shuangcheng Ma
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Correspondence to An Liu.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 428–431.

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Jing, W., Zhao, X., Liu, A. et al. Two New Nitrogenous Compounds from the Seeds of Brassica napus. Chem Nat Compd 58, 501–505 (2022). https://doi.org/10.1007/s10600-022-03719-5

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  • DOI: https://doi.org/10.1007/s10600-022-03719-5

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