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New Triterpenoid and Anti-Inflammatory Constituents of Eriobotrya deflexa f. deflexa

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A new triterpenoid, methyl 2α-(4-hydroxybenzoyl)oxy-3β-hydroxy-urs-12-en-28-oate (1), has been isolated from the leaves of Eriobotrya deflexa f. deflexa, together with five known compounds, quercetin (2), kaempferol 3-O-β-glucoside (3), naringenin (4), ursolic acid (5), and euscaphic acid (6). The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, quercetin (2), naringenin (4), and ursolic acid (5) showed potent inhibition with IC50 values of 31.74 ± 1.87, 24.25 ± 1.68, and 18.05 ± 1.02 μM, respectively, against LPS-induced NO generation.

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ACKNOWLEDGMENT

This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 109-2320-B-010-029-MY3) awarded to Prof. J.-J. Chen. This work was also supported by grants from Pingtung Christian Hospital (PS 110030) and Cardinal Tien Junior College of Health and Management (CTCN-110-02). We gratefully thank Ms Shou-Ling Huang and Dr. Iren Wang for assistance in the NMR experiments at the Instrumentation Center at NTU, which is supported by the Ministry of Science and Technology, Taiwan. Hui-Ming Chen and Chien-Ming Huang have contributed equally to this manuscript.

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Authors and Affiliations

  1. Department of Nursing, Cardinal Tien Junior College of Health and Management, 231, New Taipei City, Taiwan

    Hui-Ming Chen

  2. Division of Pharmacy, Cheng Hsin General Hospital, 112, Taipei, Taiwan

    Chien-Ming Huang

  3. Department of Pharmacy, Tajen University, 907, Yanpu Township, Pingtung, Taiwan

    Li-Chai Chen

  4. Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University, 112, Taipei, Taiwan

    Chang-Syun Yang & Jih-Jung Chen

  5. Institute of Microbiology and Immunology, National Defense Medical Center, 114, Taipei, Taiwan

    Tsung-Hsien Chang

  6. Department of Biological Sciences, National Sun Yat-Sen University, 804, Kaohsiung, Taiwan

    Chun-Lin Chen

  7. National Museum of Marine Biology and Aquarium, 944, Checheng Township, Pingtung, Taiwan

    Ping-Jyun Sung

  8. Chung-Jen College of Nursing, Health Sciences and Management, 600, Chiayi, Taiwan

    Wen-Lung Kuo

  9. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

    Ming-Jen Cheng

  10. Department of Pharmacy, Pingtung Christian Hospital, 900, Pingtung City, Pingtung, Taiwan

    Jen-Wen Hsiao

  11. Department of Medical Research, China Medical University Hospital, China Medical University, 404, Taichung, Taiwan

    Jih-Jung Chen

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  1. Hui-Ming Chen
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  2. Chien-Ming Huang
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  3. Li-Chai Chen
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  4. Chang-Syun Yang
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  5. Tsung-Hsien Chang
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  6. Chun-Lin Chen
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  7. Ping-Jyun Sung
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  8. Wen-Lung Kuo
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  9. Ming-Jen Cheng
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  10. Jen-Wen Hsiao
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  11. Jih-Jung Chen
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Corresponding author

Correspondence to Jih-Jung Chen.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 424–427.

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Chen, HM., Huang, CM., Chen, LC. et al. New Triterpenoid and Anti-Inflammatory Constituents of Eriobotrya deflexa f. deflexa. Chem Nat Compd 58, 496–500 (2022). https://doi.org/10.1007/s10600-022-03718-6

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  • DOI: https://doi.org/10.1007/s10600-022-03718-6

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