Skip to main content
SpringerLink
Log in

Talaromycone A, a New 2-Benzopyran-1,3-Dione from Talaromyces wortmannii LGT-4

  • Published:
Chemistry of Natural Compounds Aims and scope

A new 2-benzopyran-1,3-dione, talaromycone A (1), was isolated from Talaromyces wortmannii LGT-4, an endophytic fungus of Tripterygium wilfordii. The structure of 1 was elucidated by IR, MS, and 1D and 2D NMR spectra and comparison of the experimental and electronic circular dichroism (ECD) data. The phosphoinositide 3-kinase (PI3Kα) inhibitory activities of 1 was also tested. The compound did not show good biological activity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig 1
Fig. 2

Similar content being viewed by others

References

  1. C. W. Bacon and J. F. White, Symbiosis, 68, 87 (2016).

    Article  CAS  Google Scholar 

  2. G. Strobel, B. Daisy, U. Castillo, and J. Harper, J. Nat. Prod., 67, 257 (2004).

    Article  CAS  Google Scholar 

  3. M. M. Zhai, J. Li, C. X. Jiang, Y. P. Shi, D. L. Di, C. Phillip, and Q. X. Wu, Nat. Prod. Bioprospect., 6, 1 (2016).

    Article  CAS  Google Scholar 

  4. H. E. Ding, Z. D. Yang, L. Sheng, S. Y. Zhou, S. Li, and X. J. Yao, Tetrahedron Lett., 56, 6754 (2015).

    Article  CAS  Google Scholar 

  5. G. C. Fu, Z. D. Yang, S. Y. Zhou, X. M. Li, H. T. Yu, X. J. Yao, J. G. Fang, Z. M. Shu, H. Y. Xue, and Y. G. Wang, Tetrahedron Lett., 57, 4608 (2016).

    Article  CAS  Google Scholar 

  6. J. W. Zhao, Z. D. Yang, S. Y. Zhou, and L. J. Yang, Phytochem. Lett., 29, 115 (2019).

    Article  CAS  Google Scholar 

  7. X. W. Chen, C. W. Li, C. B. Cui, W. Hua, T. J. Zhu, and Q. Q. Gu, Mar. Drugs, 12, 3116 (2014).

    Article  Google Scholar 

  8. B. B. Jarvis, G. P. Stahly, G. Pavanasasivam, J. O. Midiwo, T. DeSilva, C. E. Holmlund, E. P. Mazzola, and R. F. Geoghegan, J. Org. Chem., 47, 1117 (1982).

    Article  CAS  Google Scholar 

  9. M. Takeshita and T. Sato, Chem. Pharm. Bull., 37, 1085 (1989).

    Article  CAS  Google Scholar 

  10. W. A. Ayer and L. S. Trifonov, J. Nat. Prod., 56, 85 (2004).

    Article  Google Scholar 

  11. B. B. Jarvis, S. J. Wang, and H. L. Ammon, J. Nat. Prod., 59, 254 (1996).

    Article  CAS  Google Scholar 

  12. S. Lin, T. Shi, K. Y. Chen, Z. X. Zhang, L. Shan, Y. H. Shen, and W. D. Zhang, Chem. Commun., 47, 10413 (2011).

    Article  CAS  Google Scholar 

  13. G. A. Suarez-Ortiz, C. M. Cerda-Garcia-Rojas, M. Fragoso-Serrano, R. Pereda-Miranda, J. Nat. Prod., 80, 181 (2017).

    Article  CAS  Google Scholar 

Download references

Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (No. 21762027) and Leading Academic Discipline Project of Lanzhou University of Technology (2018).

Author information

Authors and Affiliations

  1. School of Life Science and Engineering, Lanzhou University of Technology, 730050, Lanzhou, P. R. China

    Wen-Lin Guo, Zhong-Duo Yang, Xiao-Fei Li, Li-Jun Yang & Zong-Mei Shu

  2. Department of Chemistry, Lanzhou University, 730000, Lanzhou, P. R. China

    Xing Yang & Xiao-Jun Yao

  3. The Provincial Education Key Laboratory of Screening, Evaluation and Advanced Processing of Traditional Chinese Medicine and Tibetan Medicine, School of Life Science and Engineering, Lanzhou University of Technology, 730050, Lanzhou, P. R. China

    Zong-Mei Shu

Authors
  1. Wen-Lin Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zhong-Duo Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xiao-Fei Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Xing Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Li-Jun Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xiao-Jun Yao
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Zong-Mei Shu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhong-Duo Yang.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 383–385.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Guo, WL., Yang, ZD., Li, XF. et al. Talaromycone A, a New 2-Benzopyran-1,3-Dione from Talaromyces wortmannii LGT-4. Chem Nat Compd 58, 446–449 (2022). https://doi.org/10.1007/s10600-022-03709-7

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10600-022-03709-7

Keywords

Search

Navigation