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A New Calamenene Sesquiterpene Glycoside from the Bark of Thespesia populnea

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Chemistry of Natural Compounds Aims and scope

One new calamenene sesquiterpene glycoside, (1R,2R,3S,4S)-4-isopropyl-1,6-dimethyl-1,2,3,4- tetrahydronaphthalene-2,7-diol 3-O-β-D-glucopyranoside (1), along with five known compounds including betulinic acid (2), oleanolic acid (3), maslinic acid (4), daucosterol (5), and 6′-O-acetyl-daucosterol (6), was isolated from the bark of Thespesia populnea. The n-hexane, dichloromethane, and ethyl acetate extracts showed inhibitory effects against four strains of microorganisms, E. coli, S. aureus, A. niger, and F. oxysporum, with MIC values of 50–200 μg/mL while the acetone extract only exhibited antifungal activity against A. niger with MIC 50 μg/mL.

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Correspondence to Tram Thi Thu Nguyen.

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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2022, pp. 394–397.

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Nguyen, D.P., Le, Y.K., Thai, N.T.T. et al. A New Calamenene Sesquiterpene Glycoside from the Bark of Thespesia populnea. Chem Nat Compd 58, 459–463 (2022).

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